SCHEMBL514283

SCHEMBL514283

C[CH]OC(=O)Nc1cccc(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.59
ALDH1A1 P00352 5/20 0.59
LMNA P02545 4/20 0.59
GAA P10253 3/20 0.59
TP53 P04637 1/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
HTT P42858 2/20 0.57
RAB9A P51151 1/20 0.57
NPSR1 Q6W5P4 3/20 0.57
XBP1 P17861 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.56
PKM P14618 2/20 0.55
HSP90AA1 P07900 1/20 0.53
KDM4E B2RXH2 1/20 0.52
TDP1 Q9NUW8 1/20 0.51
P2RX1 P51575 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23167891 0.87 MAPT (0.61) MAPTALDH1A1LMNAGAATP53
SCHEMBL515008 0.84 SMN1; SMN2 (0.68) MAPTALDH1A1LMNAGAATP53
SCHEMBL1013325 0.81 RXFP1 (0.73) MAPTALDH1A1LMNAGAATP53
SCHEMBL30042580 0.81 RXFP1 (0.73) MAPTALDH1A1LMNAGAATP53
SCHEMBL515007 0.80 MAPT (0.62) MAPTALDH1A1LMNAGAATP53
SCHEMBL9335041 0.79 HPGD (0.62) MAPTALDH1A1LMNAGAATP53
SCHEMBL7565660 0.79 SMN1; SMN2 (0.62) MAPTALDH1A1LMNAGAATP53
SCHEMBL505220 0.78 RXFP1 (0.69) MAPTALDH1A1LMNAGAATP53
SCHEMBL30022965 0.78 RXFP1 (0.69) MAPTALDH1A1LMNAGAATP53
SCHEMBL20963100 0.78 TP53 (0.60) MAPTALDH1A1LMNAGAATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023210623-A1 HALOALKYL SULFONE ANILIDE COMPOUND AND HERBICIDE CONTAINING SAME 株式会社エス・ディー・エス バイオテック 2023-11-02 WO disclosed
WO-2014184071-A1 MIXTURES OF HALOALKYLSULFONANILIDE DERIVATIVES AND HERBICIDES SYNGENTA LIMITED (GB) 2014-11-20 WO disclosed
WO-2014184070-A1 MIXTURES OF HALOALKYLSULFONANILIDE DERIVATIVES AND HERBICIDES SYNGENTA LIMITED (GB) 2014-11-20 WO disclosed
EP-2420493-A1 HALOALKYLSULFONANILIDE DERIVATIVE Nissan Chemical Industries, Ltd. (JP) 2012-02-22 EP disclosed
US-20120029187-A1 HALOALKYLSULFONANILIDE DERIVATIVE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-02-02 US disclosed
EP-2336104-A1 ORTHO-SUBSTITUTED HALOALKYLSULFONANILIDE DERIVATIVE AND HERBICIDE Nissan Chemical Industries, Ltd. (JP) 2011-06-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120029187-A1 HALOALKYLSULFONANILIDE DERIVATIVE CBR3, CBR1, HDHD5 MAPT 4824/4885ALDH1A1 1574/4885LMNA 4076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.