Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 2/20 | 0.74 |
| ▸ | ESR1 | P03372 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | G6PD | P11413 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | DAB2IP | Q5VWQ8 | 1/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.63 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | STS | P08842 | 3/20 | 0.60 |
| ▸ | HSD17B1 | P14061 | 8/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10054959 | 0.91 | SHBG (0.70) | SHBGESR1KDM4EMEN1LMNA | |
| SCHEMBL4083803 | 0.91 | SHBG (0.70) | SHBGESR1KDM4EMEN1LMNA | |
| SCHEMBL10439769 | 0.90 | HSD17B1 (0.70) | SHBGESR1KDM4EMEN1LMNA | |
| SCHEMBL4082465 | 0.90 | SHBG (0.68) | SHBGESR1KDM4EMEN1LMNA | |
| SCHEMBL4078960 | 0.88 | SHBG (0.65) | SHBGESR1KDM4EMEN1LMNA | |
| SCHEMBL14252885 | 0.88 | ESR1 (0.71) | SHBGESR1MEN1LMNAGAA | |
| SCHEMBL6409438 | 0.88 | SHBG (0.65) | SHBGESR1KDM4EMEN1LMNA | |
| SCHEMBL4075005 | 0.88 | HSD17B1 (0.69) | SHBGESR1KDM4EMEN1LMNA | |
| SCHEMBL4825753 | 0.88 | STS (0.68) | SHBGESR1KDM4EMEN1LMNA | |
| SCHEMBL7064718 | 0.88 | SHBG (0.65) | SHBGESR1KDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773754-A2 | METHODS AND COMPOSITIONS FOR TREATING CANCER | Massachussets Institute of Technology (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2005086974-A2 | METHODS AND COMPOSITIONS FOR TREATING CANCER | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-09-22 | — | — | WO | claimed |
| EP-0138504-B1 | STEROID DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-07-20 | — | — | EP | disclosed |