SCHEMBL5144490

SCHEMBL5144490

O=C1NCc2ccccc2S1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.45
CA9 Q16790 1/20 0.45
ALDH1A1 P00352 3/20 0.44
HPGD P15428 3/20 0.44
KDM4E B2RXH2 2/20 0.44
RYR2 Q92736 1/20 0.41
PARP1 P09874 2/20 0.38
PDPK1 O15530 1/20 0.38
PARP10 Q53GL7 1/20 0.38
PARP11 Q9NR21 1/20 0.38
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
ATM Q13315 1/20 0.37
MAPT P10636 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
ALOX15 P16050 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CYP1A2 P05177 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4510651 0.75 GAA (0.52) CA12CA9ALDH1A1HPGDKDM4E
SCHEMBL10558990 0.73 RYR2 (0.48) CA12CA9ALDH1A1HPGDKDM4E
SCHEMBL8526616 0.72 RYR2 (0.47) CA12CA9ALDH1A1HPGDKDM4E
SCHEMBL13939432 0.69 CA12 (0.63) CA12CA9ALDH1A1HPGDKDM4E
SCHEMBL9710518 0.68 CA12 (0.39) CA12CA9RYR2MEN1KMT2A
SCHEMBL14061414 0.67 CA12 (0.56) CA12CA9PARP1PDPK1PARP10
SCHEMBL7146808 0.67 ALOX15 (0.51) ALDH1A1HPGDKDM4ERYR2MEN1
SCHEMBL1498003 0.67 ALDH1A1 (0.59) ALDH1A1HPGDKDM4ERYR2MEN1
SCHEMBL10463774 0.67 ALDH1A1 (0.64) ALDH1A1HPGDKDM4EMEN1KMT2A
SCHEMBL8562468 0.66 NOX1 (0.58) HPGDMEN1KMT2ALMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1579011-A4 MODULATION OF DEATH-ASSOCIATED PROTEIN KINASE 1 EXPRESSION ISIS PHARMACEUTICALS INC (US) 2007-10-31 EP disclosed
EP-1579006-A2 MODULATION OF JAGGED 1 EXPRESSION Isis Pharmaceuticals, Inc. (US) 2005-09-28 EP disclosed
EP-1579011-A2 MODULATION OF DEATH-ASSOCIATED PROTEIN KINASE 1 EXPRESSION Isis Pharmaceuticals, Inc. (US) 2005-09-28 EP disclosed
EP-1532160-A2 ANTISENSE MODULATION OF INSULIN-LIKE GROWTH FACTOR 2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2005-05-25 EP disclosed
WO-2004053083-A2 MODULATION OF FETOPROTEIN TRANSCRIPTION FACTOR EXPRESSION ISIS PHARMACEUTICALS INC. (US) 2004-06-24 WO disclosed
WO-2004048531-A2 MODULATION OF DEATH-ASSOCIATED PROTEIN KINASE 1 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-06-10 WO disclosed
WO-2004048601-A2 MODULATION OF B7H EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-06-10 WO disclosed
WO-2004048325-A2 MODULATION OF JAGGED 1 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-06-10 WO disclosed
US-20040110156-A1 Modulation of NRF expression ISIS PHARMACEUTICALS INC. 2004-06-10 US disclosed
WO-2004048533-A2 MODULATION OF FORKHEAD BOX C2 EXPRESSION ISIS, PHARMACEUTICALS (US) 2004-06-10 WO disclosed
WO-2004048534-A2 MODULATION OF CYTOKINE-INDUCIBLE KINASE EXPRESSION ISIS PARMACEUTICALS, INC. (US) 2004-06-10 WO disclosed
WO-2004046326-A2 MODULATION OF INTERLEUKIN 22 RECEPTOR EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-06-03 WO disclosed
WO-2004046325-A2 MODULATION OF SERINE/THREONINE KINASE 16 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-06-03 WO disclosed
WO-2004045527-A2 MODULATION OF NIMA-RELATED KINASE 6 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-06-03 WO disclosed
WO-2004011623-A2 ANTISENSE MODULATION OF PTPRA EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-02-05 WO disclosed
WO-2004005461-A2 ANTISENSE MODULATION OF INSULIN-LIKE GROWTH FACTOR 2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-01-15 WO disclosed
WO-2003105754-A2 ANTISENSE MODULATION OF VEGF-B EXPRESSION ISIS PHARMACEUTICALS INC. (US) 2003-12-24 WO disclosed
WO-2003106711-A1 ANTISENSE MODULATION OF EXTRACELLULAR-SIGNAL REGULATED KINASE-6 EXPRESSION ISIS PHARMACEUTICALS INC. (US) 2003-12-24 WO disclosed
EP-1328536-A1 ANTISENSE MODULATION OF GLIOMA-ASSOCIATED ONCOGENE-1 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2003-07-23 EP disclosed
WO-2002020549-A1 ANTISENSE MODULATION OF GLIOMA-ASSOCIATED ONCOGENE-1 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2002-03-14 WO disclosed