Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL127217 | 0.98 | TERT (0.42) | TERTSLC16A3SLC16A1POLBKDM4E | |
| Bromide SCHEMBL1146683 | 0.97 | TERT (0.41) | TERTSLC16A3SLC16A1POLBKDM4E | |
| SCHEMBL1472456 | 0.95 | TERT (0.40) | TERTSLC16A3SLC16A1POLBKDM4E | |
| SCHEMBL1472495 | 0.95 | TERT (0.40) | TERTSLC16A3SLC16A1POLBKDM4E | |
| Iodide SCHEMBL1470298 | 0.94 | TERT (0.39) | TERTSLC16A3SLC16A1POLBKDM4E | |
| Bromide SCHEMBL12988304 | 0.92 | TERT (0.40) | TERTSLC16A3SLC16A1POLBKDM4E | |
| Bromide SCHEMBL12987783 | 0.91 | TERT (0.39) | TERTSLC16A3SLC16A1POLBKDM4E | |
| SCHEMBL1472472 | 0.91 | TERT (0.39) | TERTSLC16A3SLC16A1POLBKDM4E | |
| SCHEMBL1470384 | 0.90 | TERT (0.38) | TERTSLC16A3SLC16A1POLBKDM4E | |
| Iodide SCHEMBL1472479 | 0.90 | TERT (0.38) | TERTSLC16A3SLC16A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539988-A4 | HOMOCYSTEINE ASSAY ADAPTABLE TO SCREENING | ANTICANCER INC (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1539988-A2 | HOMOCYSTEINE ASSAY ADAPTABLE TO SCREENING | ANTICANCER, INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004023097-A2 | HOMOCYSTEINE ASSAY ADAPTABLE TO SCREENING | ANTICANCER, INC. (US) | 2004-03-18 | — | — | WO | disclosed |