Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5144884 | 0.98 | ABCB1 (0.44) | SLC18A3ABCB1ALDH1A1MAPTHPGD | |
| SCHEMBL5144569 | 0.85 | MAPT (0.44) | SLC18A3ABCB1ALDH1A1MAPTHPGD | |
| SCHEMBL5146384 | 0.84 | ALDH1A1 (0.47) | SLC18A3ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL5214576 | 0.84 | ABCB1 (0.44) | SLC18A3ABCB1ALDH1A1MAPTHPGD | |
| SCHEMBL10555746 | 0.84 | SLC18A3 (0.56) | SLC18A3ABCB1ALDH1A1MAPTHPGD | |
| SCHEMBL14378540 | 0.81 | SLC18A3 (0.41) | SLC18A3ABCB1ALDH1A1MAPTHPGD | |
| SCHEMBL10553065 | 0.81 | SLC18A3 (0.44) | SLC18A3ABCB1ALDH1A1MAPTHPGD | |
| SCHEMBL5147209 | 0.80 | SLC18A3 (0.39) | SLC18A3ABCB1ALDH1A1MEN1KMT2A | |
| SCHEMBL13587962 | 0.77 | POLB (0.53) | POLBUSP2ALOX15TSHR | |
| SCHEMBL10553158 | 0.76 | USP2 (0.54) | HPGDPOLBUSP2ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551420-A4 | ARYL PHOSPHATE DERIVATIVES WITH SELECTIVE ACTIVITY AGAINST ADENOVIRUS AND HIV | PARKER HUGHES INST (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1575591-A4 | HETEROCYCLES AND USES THEREOF | ARIAD PHARMA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| US-7238679-B2 | Heterocycles and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2007-07-03 | — | — | US | disclosed |
| EP-1453492-B1 | USE OF QUINAZOLINES TO TREAT T-CELL MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2007-01-24 | — | — | EP | disclosed |
| US-7157467-B2 | Administering compound such as 6-methoxy-4-(2,3-methylenedioxyanilino)-7-(3-morpholinopropoxy)quinazoline for therapy of an autoimmune disease or medical condition selected from transplant rejection and rheumatoid arthritis | ASTRAZENECA AB (SE) | 2007-01-02 | — | — | US | disclosed |
| US-7115615-B2 | Quinazoline derivatives | ASTRAZENECA (SE) | 2006-10-03 | — | — | US | disclosed |
| EP-1575591-A1 | HETEROCYCLES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2005-09-21 | — | — | EP | disclosed |
| US-6939866-B2 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2005-09-06 | — | — | US | disclosed |
| EP-1551420-A1 | ARYL PHOSPHATE DERIVATIVES WITH SELECTIVE ACTIVITY AGAINST ADENOVIRUS AND HIV | Parker Hughes Institute (US) | 2005-07-13 | — | — | EP | disclosed |
| US-6849625-B2 | Quinazoline derivatives with anti-tumour activity | ASTRAZENECA AB (SE) | 2005-02-01 | — | — | US | disclosed |
| US-20050014773-A1 | Therapeutic use | ASTRAZENACA AB (SE) | 2005-01-20 | — | — | US | disclosed |
| US-20040171586-A1 | Heterocycles and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2004-09-02 | — | — | US | disclosed |
| WO-2004058267-A1 | HETEROCYCLES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2003105863-A1 | ARYL PHOSPHATE DERIVATIVES WITH SELECTIVE ACTIVITY AGAINST ADENOVIRUS AND HIV | PARKER HUGHES INSTITUTE (US) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014773-A1 | Therapeutic use | CD4, HLA-DRB1, CD74 | SLC18A3 1355/4885ABCB1 661/4885ALDH1A1 315/4885 |
| US-20040171586-A1 | Heterocycles and uses thereof | CBR1, CBR3, RCOR1 | SLC18A3 3355/4885ABCB1 2320/4885ALDH1A1 3956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.