Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | HPGD | P15428 | 3/20 | 0.76 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | RECQL | P46063 | 3/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL28541235 | 1.00 | ALDH1A1 (0.76) | ALDH1A1MEN1MAPTHPGDALOX12 | |
| Pyrophosphoric Acid SCHEMBL5144731 | 0.87 | TDP1 (0.64) | ALDH1A1MEN1MAPTHPGDALOX12 | |
| SCHEMBL63786 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL28687762 | 0.85 | ALDH1A1 (0.94) | ALDH1A1MEN1MAPTHPGDALOX12 | |
| Water SCHEMBL28157096 | 0.85 | ALDH1A1 (0.94) | ALDH1A1MEN1MAPTHPGDALOX12 | |
| SCHEMBL28332738 | 0.85 | ALDH1A1 (0.94) | ALDH1A1MEN1MAPTHPGDALOX12 | |
| SCHEMBL28150916 | 0.85 | — | — | |
| Sulfuric Acid SCHEMBL28535569 | 0.81 | ALDH1A1 (0.76) | ALDH1A1MEN1MAPTHPGDALOX12 | |
| Methacrylic Acid SCHEMBL12465612 | 0.73 | MEN1 (0.61) | ALDH1A1MEN1MAPTHPGDALOX12 | |
| Benzoquinone SCHEMBL29111552 | 0.73 | TDP1 (0.61) | ALDH1A1MEN1MAPTHPGDALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112641781-B | SARMs compounds containing ester-based aromatic propionamide and application of metabolites thereof in preparation of anti-new coronavirus drugs | 长春金赛药业有限责任公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-113368108-A | Application of selective androgen receptor modulator and composition thereof in preparation of novel coronavirus resistant medicines | 宁波耆健医药科技有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-112641781-A | SARMs compounds containing ester-based aromatic propionamide and application of metabolites thereof in preparation of anti-new coronavirus drugs | 宁波熙健医药科技有限公司 | 2021-04-13 | — | — | CN | disclosed |
| US-20070178527-A1 | Human platelet-derived growth factor receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-08-02 | — | — | US | disclosed |
| US-7105305-B2 | Human platelet-derived growth factor receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-09-12 | — | — | US | disclosed |
| US-6642022-B1 | Polypeptide, encoded by recombinant nucleic acid; antagonists can be used for treatment of atherosclerosis and cancer; use for evaluating new drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-11-04 | — | — | US | disclosed |
| US-6566075-B1 | Detection of modulators of human platelet-derived growth factor (hPDGF) receptor binding activity; obtain mammalian cells, incubate with modulator, monitor adjustment in binding activity, adjustment in activity indicates modulator | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-05-20 | — | — | US | disclosed |
| US-20030017535-A1 | Human platelet-derived growth factor receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) | 2003-01-23 | — | — | US | disclosed |
| US-6475782-B1 | Human platelet-derived growth factor receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-11-05 | — | — | US | disclosed |
| US-6372438-B1 | OBTAINING TRANSFORMED MAMMALIAN CELLS COMPRISING A RECOMBINANT NUCLEIC ACID ENCODING A HPDGF-R POLYPEPTIDE; INCUBATING TRANSFORMED MAMMALIAN CELLS WITH COMPOUND, AND INCUBATING WITOUT COMPOUND; COMPARING ACTIVATION IN TEST CELLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-04-16 | — | — | US | disclosed |
| US-6110737-A | Human platelet-derived growth factor receptor, type A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-08-29 | — | — | US | disclosed |
| US-6043211-A | ADDING TO A FIRST PROTEIN A PEPTIDE ANALOGUE OF A PHOSPHORYLATED REGION, WHEREUPON THE BINDING OF SAID FIRST PROTEIN TO SAID SECOND PROTEIN IS INHIBITED | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0811686-A2 | Human platelet-derived growth factor receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0811685-A2 | Human platelet-derived growth factor receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0572505-A4 | HUMAN PLATELET-DERIVED GROWTH FACTOR RECEPTORS | UNIV CALIFORNIA (US) | 1996-08-28 | — | — | EP | disclosed |
| EP-0572505-A1 | HUMAN PLATELET-DERIVED GROWTH FACTOR RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992013870-A1 | HUMAN PLATELET-DERIVED GROWTH FACTOR RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-08-20 | — | — | WO | disclosed |
| EP-0327369-A2 | Human plalelet-derived growth factor receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1989-08-09 | — | — | EP | disclosed |