Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.57 |
| ▸ | BRAF | P15056 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8364174 | 0.89 | EGFR (0.75) | EGFRERBB2CLK4 | |
| Hydrochloric Acid SCHEMBL8810261 | 0.88 | EGFR (0.74) | EGFRERBB2CLK4 | |
| SCHEMBL4740851 | 0.87 | EGFR (0.66) | EGFRMAPK1KDM4EHTTMAPT | |
| SCHEMBL642238 | 0.84 | EGFR (0.71) | EGFRMAPTERBB2BRAFLMNA | |
| SCHEMBL17836949 | 0.84 | EGFR (0.70) | EGFRRETKDR | |
| SCHEMBL7766632 | 0.83 | EGFR (0.57) | EGFRMAPTGRM1ERBB2BRAF | |
| SCHEMBL6954080 | 0.83 | EGFR (1.00) | EGFRMAPK1KDM4EHTTMAPT | |
| Hydrochloric Acid SCHEMBL8305110 | 0.82 | EGFR (0.51) | EGFRKDM4EHTTMAPTGRM1 | |
| SCHEMBL642835 | 0.81 | EGFR (0.64) | EGFRERBB2LMNAKDR | |
| SCHEMBL642834 | 0.81 | EGFR (0.64) | EGFRERBB2LMNAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575591-A4 | HETEROCYCLES AND USES THEREOF | ARIAD PHARMA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| US-7238679-B2 | Heterocycles and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2007-07-03 | — | — | US | disclosed |
| EP-1575591-A1 | HETEROCYCLES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2005-09-21 | — | — | EP | disclosed |
| US-20040171586-A1 | Heterocycles and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2004-09-02 | — | — | US | disclosed |
| WO-2004058267-A1 | HETEROCYCLES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171586-A1 | Heterocycles and uses thereof | CBR1, CBR3, RCOR1 | EGFR 1508/4885MAPK1 3766/4885KDM4E 3501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.