Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.70 |
| ▸ | KDR | P35968 | 8/20 | 0.70 |
| ▸ | RET | P07949 | 3/20 | 0.70 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 3/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.58 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.56 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.56 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.56 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240218 | 0.95 | EGFR (0.79) | EGFRKDRRETLCKAURKA | |
| SCHEMBL13404528 | 0.92 | EGFR (0.71) | EGFRKDRRETLCKAURKA | |
| SCHEMBL8809158 | 0.87 | EGFR (0.67) | EGFRKDRRETAURKAAURKB | |
| SCHEMBL19885291 | 0.86 | EGFR (0.65) | EGFRKDRRETLCKAURKA | |
| Hydrochloric Acid SCHEMBL3533953 | 0.84 | AURKB (0.86) | EGFRKDRAURKAAURKBMAPK14 | |
| SCHEMBL1999903 | 0.84 | EGFR (0.74) | EGFRKDRRETLCKAURKA | |
| Hydrochloric Acid SCHEMBL28325957 | 0.84 | AURKB (0.66) | EGFRKDRRETLCKAURKA | |
| SCHEMBL5144877 | 0.84 | EGFR (0.70) | EGFRKDRRET | |
| SCHEMBL14964683 | 0.83 | EGFR (0.80) | EGFRKDRRETLCKRIPK2 | |
| SCHEMBL6688859 | 0.83 | KDR (0.67) | EGFRKDRRETLCKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9452220-B2 | Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2016-09-27 | — | — | US | disclosed |
| US-20160175453-A1 | COUPLING COMPOUNDS OF NSAID ANTI-INFLAMMATORY AND ANALGESIC DRUGS AND EGFR KINASE INHIBITORS, SYNTHESIS METHODS AND APPLICATIONS THEREOF | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2016-06-23 | — | — | US | disclosed |
| CN-103483275-B | The coupling compound of NSAID class anti-inflammatory analgesic medicine and EGFR kinase inhibitor and synthetic method thereof and application | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2015-09-02 | — | — | CN | disclosed |
| CN-103483275-A | Coupling compound of NSAID anti-inflammatory pain killers and EGFR kinase inhibitor and synthetic method and application of coupling compound | GUANGZHOU INST BIOMED & HEALTH | 2014-01-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160175453-A1 | COUPLING COMPOUNDS OF NSAID ANTI-INFLAMMATORY AND ANALGESIC DRUGS AND EGFR KINASE INHIBITORS, SYNTHESIS METHODS AND APPLICATIONS THEREOF | EGFR, CHUK, ERBB2 | EGFR 1/4885KDR 132/4885RET 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.