Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 2/20 | 0.44 |
| ▸ | LAP3 | P28838 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SCN4A | P35499 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147638 | 0.98 | NPSR1 (0.54) | NPSR1MEN1KMT2ALMNARECQL | |
| SCHEMBL131325 | 0.94 | NPSR1 (0.50) | NPSR1MEN1KMT2ALMNARECQL | |
| SCHEMBL17008884 | 0.82 | PARP10 (0.51) | NPSR1MEN1KMT2ALMNARECQL | |
| SCHEMBL18718104 | 0.81 | CA1 (0.47) | NPSR1MEN1KMT2ALMNARECQL | |
| SCHEMBL1363819 | 0.81 | F2 (0.56) | NPSR1MEN1KMT2ALMNARECQL | |
| Hydrochloric Acid SCHEMBL7387182 | 0.80 | F2 (0.55) | NPSR1MEN1KMT2ALMNARECQL | |
| Hydrochloric Acid SCHEMBL7422244 | 0.80 | F2 (0.55) | NPSR1MEN1KMT2ALMNARECQL | |
| SCHEMBL1905659 | 0.78 | NPSR1 (0.58) | NPSR1MEN1KMT2ALMNARECQL | |
| SCHEMBL17126242 | 0.77 | NPSR1 (0.43) | NPSR1MEN1KMT2ALMNARECQL | |
| SCHEMBL23542548 | 0.76 | ALDH1A1 (0.45) | KMT2ATDP1SRCLAP3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615946-B1 | PROTEOLYTIC AND COVALENT ANTIBODIES | PAUL SUDHIR (US) | 2020-05-06 | — | — | EP | disclosed |
| US-9006388-B2 | Covalent attachment of ligands to nucleophilic proteins guided by non-covalent | Paul, Sudhir (US) | 2015-04-14 | — | — | US | disclosed |
| US-8980646-B2 | Proteolytic and covalent antibodies | PAUL, SUDHIR (US) | 2015-03-17 | — | — | US | disclosed |
| US-20070179083-A1 | Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding | COVALENT BIOSCIENCE INCORPORATED | 2007-08-02 | — | — | US | disclosed |
| US-20070105092-A1 | Proteolytic and covalent antibodies | COVALENT BIOSCIENCE INCORPORATED | 2007-05-10 | — | — | US | disclosed |
| EP-1615946-A2 | PROTEOLYTIC AND COVALENT ANTIBODIES | The University of Texas (US) | 2006-01-18 | — | — | EP | disclosed |
| EP-1610808-A2 | COVALENT ATTACHMENT OF LIGANDS TO NUCLEOPHILIC PROTEINS GUIDED BY NON-COVALENT BINDING | University of Texas Medical School (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004087059-A2 | COVALENT ATTACHMENT OF LIGANDS TO NUCLEOPHILIC PROTEINS GUIDED BY NON-COVALENT BINDING | THE UNIVERSITY OF TEXAS (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004087735-A2 | PROTEOLYTIC AND COVALENT ANTIBODIES | THE UNIVERSITY OF TEXAS (US) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179083-A1 | Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding | FABP1, FPR1, ADGRF1 | NPSR1 632/4885MEN1 4768/4885KMT2A 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.