Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 14/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11167375 | 1.00 | TBXAS1 (0.47) | TBXAS1CYP11B1CYP11B2PARP1MCL1 | |
| SCHEMBL11172992 | 0.99 | CYP11B1 (0.48) | TBXAS1CYP11B1CYP11B2PARP1MCL1 | |
| SCHEMBL11167802 | 0.89 | CYP11B1 (0.45) | TBXAS1CYP11B1CYP11B2PARP1 | |
| SCHEMBL11164908 | 0.89 | CYP11B1 (0.45) | TBXAS1CYP11B1CYP11B2PARP1FAAH | |
| SCHEMBL11167292 | 0.88 | CYP11B1 (0.46) | TBXAS1CYP11B1CYP11B2PARP1 | |
| SCHEMBL11174681 | 0.87 | CYP11B1 (0.51) | CYP11B1CYP11B2PARP1 | |
| SCHEMBL11164579 | 0.86 | CYP11B1 (0.52) | CYP11B1CYP11B2PARP1 | |
| SCHEMBL11162993 | 0.85 | CYP11B1 (0.43) | TBXAS1CYP11B1CYP11B2PARP1MCL1 | |
| SCHEMBL11175985 | 0.84 | CYP11B1 (0.48) | CYP11B1CYP11B2PARP1 | |
| SCHEMBL11168892 | 0.84 | TBXAS1 (0.48) | TBXAS1CYP11B1CYP11B2FAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242068-A4 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | NITROMED INC (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1242068-A1 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | Nitromed, Inc. (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001089519-A1 | THROMBOXANE INHIBITORS, COMPOSITIONS AND METHODS OF USE RELATED APPLICATIONS | NITROMED, INC. (US) | 2001-11-29 | — | — | WO | disclosed |
| WO-2001032167-A1 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | NITROMED, INC. (US) | 2001-05-10 | — | — | WO | disclosed |
| EP-0080154-A2 | N-substituted 2-pyridyl indoles, process for their preparation, pharmaceutical compositions containing them, and their therapeutical use | CIBA-GEIGY AG (CH) | 1983-06-01 | — | — | EP | disclosed |