Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5146760 | 0.89 | TBXAS1 (0.47) | CYP11B1CYP11B2TBXAS1PARP1 | |
| SCHEMBL11167375 | 0.89 | TBXAS1 (0.47) | CYP11B1CYP11B2TBXAS1PARP1 | |
| SCHEMBL11164908 | 0.88 | CYP11B1 (0.45) | CYP11B1CYP11B2HDAC1HDAC2HDAC8 | |
| SCHEMBL11172992 | 0.88 | CYP11B1 (0.48) | CYP11B1CYP11B2TBXAS1PARP1 | |
| SCHEMBL11174681 | 0.84 | CYP11B1 (0.51) | CYP11B1CYP11B2PARP1MTNR1AMAPT | |
| SCHEMBL11164579 | 0.83 | CYP11B1 (0.52) | CYP11B1CYP11B2PARP1 | |
| SCHEMBL11167292 | 0.83 | CYP11B1 (0.46) | CYP11B1CYP11B2HDAC1HDAC2HDAC8 | |
| SCHEMBL11178015 | 0.82 | CYP11B1 (0.42) | CYP11B1CYP11B2HDAC1HDAC2HDAC8 | |
| SCHEMBL11175985 | 0.82 | CYP11B1 (0.48) | CYP11B1CYP11B2PARP1MTNR1A | |
| SCHEMBL11162993 | 0.81 | CYP11B1 (0.43) | CYP11B1CYP11B2TBXAS1PARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080154-A2 | N-substituted 2-pyridyl indoles, process for their preparation, pharmaceutical compositions containing them, and their therapeutical use | CIBA-GEIGY AG (CH) | 1983-06-01 | — | — | EP | disclosed |