Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 6/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.37 |
| ▸ | BUB1 | O43683 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791645 | 0.89 | CDC7 (0.48) | CDC7ROCK2MAP4K4GSK3BCLK4 | |
| SCHEMBL5147133 | 0.84 | HSP90AA1 (0.40) | HDAC1HDAC6HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL15604108 | 0.82 | HSP90AA1 (0.53) | HDAC1HDAC6HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL18103331 | 0.75 | HSP90AA1 (0.47) | VCPHSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1220836 | 0.71 | HSP90AA1 (0.57) | CDC7ROCK2MAP4K4GSK3BCLK4 | |
| SCHEMBL5148489 | 0.70 | HDAC1 (0.45) | HDAC1HDAC6BUB1 | |
| SCHEMBL12819736 | 0.69 | HSP90AA1 (0.42) | CDC7ROCK2MAP4K4GSK3BCLK4 | |
| SCHEMBL1221297 | 0.68 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL5071782 | 0.68 | LMNA (0.52) | HDAC1HDAC6 | |
| SCHEMBL1220662 | 0.67 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185184-A1 | Carbazole derivatives | SERENEX, INC. | 2007-08-09 | — | — | US | claimed |
| US-20070185184-A1 | Carbazole derivatives | SERENEX, INC. | 2007-08-09 | — | — | US | disclosed |
| US-20070185184-A1 | Carbazole derivatives | SERENEX, INC. | 2007-08-09 | — | — | US | disclosed |
| US-20070185184-A1 | Carbazole derivatives | SERENEX, INC. | 2007-08-09 | — | — | US | disclosed |
| WO-2007035620-A2 | CARBAZOLE DERIVATIVES | SERENEX, INC. (US) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185184-A1 | Carbazole derivatives | CCNI, MKI67, CCNB3 | CDC7 62/4885ROCK2 400/4885MAP4K4 2147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.