Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 12/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CFB | P00751 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22921054 | 1.00 | RIPK1 (0.55) | RIPK1MEN1KMT2APOLBHRH3 | |
| SCHEMBL22473311 | 0.83 | RIPK1 (0.46) | RIPK1MEN1KMT2APOLBHRH3 | |
| SCHEMBL30470257 | 0.82 | RIPK1 (0.45) | RIPK1HRH3 | |
| SCHEMBL454745 | 0.82 | RIPK1 (0.46) | RIPK1PIK3CD | |
| SCHEMBL457570 | 0.82 | RIPK1 (0.46) | RIPK1PIK3CD | |
| SCHEMBL454486 | 0.82 | RIPK1 (0.46) | RIPK1PIK3CD | |
| SCHEMBL24774461 | 0.78 | MEN1 (0.38) | RIPK1MEN1KMT2ACHRNB4CHRNA3 | |
| SCHEMBL25587655 | 0.74 | RIPK1 (0.53) | RIPK1MEN1KMT2A | |
| SCHEMBL30470290 | 0.73 | RIPK1 (0.37) | RIPK1MEN1KMT2APOLBHRH3 | |
| SCHEMBL22473213 | 0.72 | RIPK1 (0.41) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551962-A4 | MITOTIC KINESIN BINDING SITE | MERCK & CO INC (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1551962-A2 | MITOTIC KINESIN BINDING SITE | Merck & Co., Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004087050-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004004652-A2 | MITOTIC KINESIN BINDING SITE | MERCK & CO., INC. (US) | 2004-01-15 | — | — | WO | disclosed |