Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 7/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL454745 | 1.00 | RIPK1 (0.46) | RIPK1JAK2NTRK1PDE5AMAOB | |
| SCHEMBL454486 | 1.00 | RIPK1 (0.46) | RIPK1JAK2NTRK1PDE5AMAOB | |
| SCHEMBL454071 | 0.84 | RIPK1 (0.44) | RIPK1PDE5AMAOBMAOAHTR2A | |
| SCHEMBL454802 | 0.84 | RIPK1 (0.44) | RIPK1PDE5AMAOBMAOAHTR2A | |
| SCHEMBL458228 | 0.84 | RIPK1 (0.44) | RIPK1PDE5AMAOBMAOAHTR2A | |
| SCHEMBL5147205 | 0.82 | RIPK1 (0.55) | RIPK1PIK3CD | |
| SCHEMBL22921054 | 0.82 | RIPK1 (0.55) | RIPK1PIK3CD | |
| SCHEMBL4289055 | 0.81 | JAK2 (0.46) | RIPK1JAK2NTRK1MAOBPIK3CD | |
| SCHEMBL16474303 | 0.77 | JAK2 (0.44) | RIPK1JAK2NTRK1MAOBPIK3CD | |
| SCHEMBL17848946 | 0.77 | KDM1A (0.41) | RIPK1JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614062-A1 | IMIDAZO [1, 2]PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |