Acetic Acid

Acetic Acid

SCHEMBL5147236

CC(=O)O.O=C(NCC1CCCCC1)OC(C(=O)c1ccccc1)c1ccccc1

nearest known ligand 0.55

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
OPRK1 known ✓ P41145 2/20 0.51
ALDH1A1 P00352 2/20 0.52
CYP3A4 P08684 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.46
TSHR P16473 1/20 0.46
LMNA P02545 1/20 0.46
EPHX1 P07099 1/20 0.45
BCHE P06276 6/20 0.44
KLK7 P49862 1/20 0.43
OPRD1 P41143 1/20 0.43
POLB P06746 1/20 0.43
MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL4755059 0.83 LMNA (0.48) ALDH1A1OPRK1SMN1; SMN2TSHRLMNA
Acetic Acid SCHEMBL4754474 0.80 LMNA (0.53) ALDH1A1OPRK1SMN1; SMN2LMNAEPHX1
SCHEMBL4339005 0.80 TSHR (0.52) ALDH1A1OPRK1SMN1; SMN2TSHRLMNA
Acetic Acid SCHEMBL5145744 0.78 LMNA (0.51) ALDH1A1OPRK1SMN1; SMN2LMNAEPHX1
SCHEMBL771095 0.78 TSHR (0.59) ALDH1A1CYP3A4TSHRLMNAEPHX1
SCHEMBL4347373 0.77 LMNA (0.55) ALDH1A1OPRK1SMN1; SMN2LMNAEPHX1
SCHEMBL20895760 0.77 ALDH1A1 (0.62) ALDH1A1CYP3A4SMN1; SMN2LMNAPOLB
Acetic Acid SCHEMBL4757552 0.76 LMNA (0.46) ALDH1A1OPRK1SMN1; SMN2LMNAEPHX1
Bicarbonate SCHEMBL3256726 0.76 LMNA (0.54) ALDH1A1OPRK1SMN1; SMN2LMNAEPHX1
SCHEMBL20895767 0.75 ALDH1A1 (0.59) ALDH1A1CYP3A4SMN1; SMN2LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1569895-A4 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF XENOPORT INC (US) 2007-07-11 EP disclosed
EP-1569895-A1 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF Xenoport, Inc. (US) 2005-09-07 EP disclosed
EP-1404324-A4 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF XENOPORT INC (US) 2004-12-22 EP disclosed
EP-1485082-A1 METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF Xenoport, Inc. (US) 2004-12-15 EP disclosed
WO-2004052844-A1 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF XENOPORT, INC. (US) 2004-06-24 WO disclosed
EP-1404324-A2 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF Xenoport, Inc. (US) 2004-04-07 EP disclosed
WO-2003077902-A1 METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF XENOPORT, INC. (US) 2003-09-25 WO disclosed
WO-2002100347-A2 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF XENOPORT, INC. (US) 2002-12-19 WO disclosed