Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366618 | 0.79 | CYP11B1 (0.43) | CYP11B1CYP11B2HDAC6NPC1RAB9A | |
| SCHEMBL5147488 | 0.78 | MEN1 (0.33) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL5490841 | 0.75 | HTT (0.31) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL12531530 | 0.75 | CYP11B1 (0.49) | CYP11B1CYP11B2HDAC6NPC1RAB9A | |
| SCHEMBL988896 | 0.75 | CYP11B1 (0.49) | CYP11B1CYP11B2HDAC6NPC1RAB9A | |
| SCHEMBL987523 | 0.75 | CYP11B1 (0.49) | CYP11B1CYP11B2HDAC6NPC1RAB9A | |
| SCHEMBL6375451 | 0.75 | CYP11B1 (0.49) | CYP11B1CYP11B2HDAC6NPC1RAB9A | |
| SCHEMBL10899166 | 0.74 | PTGS1 (0.50) | CYP11B1CYP11B2HDAC6NPC1RAB9A | |
| SCHEMBL379478 | 0.72 | HDAC6 (0.44) | CYP11B1CYP11B2HDAC6NPC1RAB9A | |
| SCHEMBL2600215 | 0.72 | ALDH1A1 (0.50) | CYP11B1CYP11B2HDAC6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |