Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983283 | 0.79 | PTGS2 (0.41) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL5147277 | 0.78 | CYP11B1 (0.45) | ALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL23618659 | 0.64 | BCAT2 (0.43) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL10366618 | 0.64 | CYP11B1 (0.43) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL2600064 | 0.63 | CYP11B1 (0.45) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL5147356 | 0.63 | BCAT2 (0.43) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL988896 | 0.61 | CYP11B1 (0.49) | ALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL12531530 | 0.61 | CYP11B1 (0.49) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL5490841 | 0.60 | HTT (0.31) | ALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL20132762 | 0.60 | CYP11B1 (0.42) | MEN1KMT2AALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |