Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.42 |
| ▸ | RAF1 | P04049 | 4/20 | 0.39 |
| ▸ | FPR3 | P25089 | 4/20 | 0.32 |
| ▸ | FPR2 | P25090 | 4/20 | 0.32 |
| ▸ | CCKBR | P32239 | 1/20 | 0.31 |
| ▸ | SLC8A1 | P32418 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 3/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147375 | 0.90 | BRAF (0.41) | BRAFRAF1SLC8A1IKBKBF10 | |
| SCHEMBL5148397 | 0.90 | BRAF (0.43) | BRAFRAF1SLC8A1ALDH1A1IKBKB | |
| SCHEMBL5147464 | 0.81 | BRAF (0.35) | BRAFRAF1SLC8A1ALDH1A1SCN9A | |
| SCHEMBL2980490 | 0.79 | BRAF (0.40) | BRAFRAF1CCKBRSCN9A | |
| SCHEMBL2984723 | 0.77 | BRAF (0.47) | BRAFRAF1ALDH1A1IKBKBSCN9A | |
| SCHEMBL2988854 | 0.75 | BRAF (0.45) | BRAFRAF1ALDH1A1IKBKBSCN9A | |
| SCHEMBL2984512 | 0.75 | BRAF (0.46) | BRAFRAF1ALDH1A1SCN9A | |
| SCHEMBL2978240 | 0.75 | BRAF (0.46) | BRAFRAF1ALDH1A1IKBKB | |
| SCHEMBL2982070 | 0.75 | BRAF (0.46) | BRAFRAF1ALDH1A1IKBKB | |
| SCHEMBL2984342 | 0.74 | BRAF (0.50) | BRAFRAF1FPR3FPR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |