Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.41 |
| ▸ | RAF1 | P04049 | 6/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | SLC8A1 | P32418 | 4/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147344 | 0.90 | BRAF (0.42) | BRAFRAF1SLC8A1F10IKBKB | |
| SCHEMBL5148397 | 0.88 | BRAF (0.43) | BRAFRAF1SLC8A1IKBKBSCN9A | |
| SCHEMBL2985600 | 0.80 | MEN1 (0.42) | BRAFRAF1HPGDSHTR2A | |
| SCHEMBL2988386 | 0.77 | SCN9A (0.44) | BRAFRAF1HPGDSMKNK1IKBKB | |
| SCHEMBL5147464 | 0.77 | BRAF (0.35) | BRAFRAF1SLC8A1SCN9A | |
| SCHEMBL2984512 | 0.76 | BRAF (0.46) | BRAFRAF1MKNK1SCN9A | |
| SCHEMBL2984723 | 0.76 | BRAF (0.47) | BRAFRAF1MKNK1IKBKBCHUK | |
| SCHEMBL2977811 | 0.76 | BRAF (0.49) | BRAFRAF1HPGDSMKNK1NMT1 | |
| SCHEMBL2982070 | 0.75 | BRAF (0.46) | BRAFRAF1MKNK1IKBKBCHUK | |
| SCHEMBL2985285 | 0.75 | BRAF (0.48) | BRAFRAF1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |