Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 3/20 | 0.34 |
| ▸ | SLC8A1 | P32418 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148397 | 0.88 | BRAF (0.43) | BRAFSCN9ARAF1SLC8A1ALDH1A1 | |
| SCHEMBL2974375 | 0.82 | SCN9A (0.41) | BRAFSCN9ARAF1ALDH1A1ADORA2A | |
| SCHEMBL5147344 | 0.81 | BRAF (0.42) | BRAFSCN9ARAF1SLC8A1ALDH1A1 | |
| SCHEMBL2981786 | 0.80 | TSHR (0.37) | SCN9AALDH1A1 | |
| SCHEMBL2975829 | 0.78 | ALDH1A1 (0.46) | BRAFSCN9ARAF1ALDH1A1ADORA2A | |
| SCHEMBL2975039 | 0.78 | RECQL (0.38) | BRAFSCN9ARAF1ALDH1A1ADORA2A | |
| SCHEMBL5147375 | 0.77 | BRAF (0.41) | BRAFSCN9ARAF1SLC8A1 | |
| SCHEMBL2988370 | 0.75 | BRAF (0.41) | BRAFSCN9ARAF1ALDH1A1ADORA2A | |
| SCHEMBL2985538 | 0.73 | SCN9A (0.42) | BRAFSCN9ARAF1ALDH1A1ADORA2A | |
| SCHEMBL2984336 | 0.73 | MEN1 (0.42) | BRAFSCN9ARAF1ALDH1A1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |