Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.74 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.71 |
| ▸ | GSK3B | P49841 | 5/20 | 0.70 |
| ▸ | GSK3A | P49840 | 4/20 | 0.56 |
| ▸ | F5 | P12259 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147349 | 1.00 | PIK3CG (0.74) | PIK3CGPIK3CAGSK3BGSK3AF5 | |
| SCHEMBL3898790 | 0.87 | PIK3CG (0.78) | PIK3CGPIK3CAGSK3BGSK3AMEN1 | |
| SCHEMBL5146807 | 0.87 | PIK3CG (0.78) | PIK3CGPIK3CAGSK3BGSK3AMEN1 | |
| SCHEMBL3898789 | 0.87 | PIK3CG (0.78) | PIK3CGPIK3CAGSK3BGSK3AMEN1 | |
| SCHEMBL5168014 | 0.85 | PIK3CG (0.78) | PIK3CGPIK3CAGSK3BGSK3AMEN1 | |
| SCHEMBL6393236 | 0.85 | PIK3CG (1.00) | PIK3CGPIK3CAGSK3BGSK3AMEN1 | |
| SCHEMBL6393214 | 0.85 | PIK3CG (1.00) | PIK3CGPIK3CAGSK3BGSK3AMEN1 | |
| SCHEMBL5162801 | 0.85 | PIK3CG (0.78) | PIK3CGPIK3CAGSK3BGSK3AMEN1 | |
| SCHEMBL15299526 | 0.85 | PIK3CG (1.00) | PIK3CGPIK3CAGSK3BGSK3AMEN1 | |
| SCHEMBL5168019 | 0.85 | PIK3CG (0.78) | PIK3CGPIK3CAGSK3BGSK3AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718308-A4 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORP (CA) | 2007-07-18 | — | — | EP | disclosed |
| EP-1718308-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PainCeptor Pharma Corp. (CA) | 2006-11-08 | — | — | EP | disclosed |
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-12-22 | — | — | US | disclosed |
| WO-2005076695-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | NGF, BDNF, NTRK2 | PIK3CG 2749/4885PIK3CA 3916/4885GSK3B 2118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.