Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.33 |
| ▸ | USP2 | O75604 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.33 |
| ▸ | CASP1 | P29466 | 7/20 | 0.33 |
| ▸ | CASP7 | P55210 | 7/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 3/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983794 | 0.84 | MEN1 (0.31) | CYP1A2USP2ALDH1A1HSD17B10CASP1 | |
| SCHEMBL2985133 | 0.82 | MARK3 (0.36) | MAPK1CYP1A2USP2ALDH1A1CASP1 | |
| SCHEMBL5147397 | 0.82 | CXCR4 (0.34) | MAPK1BRD4KAT2BCYP1A2USP2 | |
| SCHEMBL13685201 | 0.80 | CXCR4 (0.34) | MAPK1BRD4KAT2BCYP1A2USP2 | |
| SCHEMBL2979553 | 0.80 | FGFR1 (0.34) | MAPK1CYP1A2USP2ALDH1A1HSD17B10 | |
| SCHEMBL2978356 | 0.80 | GUSB (0.39) | CYP1A2USP2ALDH1A1HSD17B10CASP1 | |
| SCHEMBL2986223 | 0.79 | FGFR1 (0.35) | MAPK1CDK9FGFR1AXL | |
| SCHEMBL2988266 | 0.79 | PDE7A (0.43) | MAPK1CYP1A2USP2ALDH1A1HSD17B10 | |
| SCHEMBL2988264 | 0.79 | PDE7A (0.43) | MAPK1CYP1A2USP2ALDH1A1HSD17B10 | |
| SCHEMBL2981950 | 0.77 | MAPK1 (0.33) | MAPK1CYP1A2USP2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-B1 | AMINOPYRIMIDINE COMPOUNDS AS PLK INHIBITORS | AMGEN INC (US) | 2012-11-14 | — | — | EP | claimed |
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |