Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 5/20 | 0.31 |
| ▸ | CASP1 | P29466 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2980191 | 0.89 | JAK2 (0.33) | CYP1A2ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL13685201 | 0.85 | CXCR4 (0.34) | CXCR4MKNK1CYP1A2ALDH1A1MEN1 | |
| SCHEMBL2977483 | 0.82 | MEN1 (0.31) | CYP1A2ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL13684926 | 0.82 | SYK (0.36) | LMNACDK4CCND1MAPK14 | |
| SCHEMBL5147385 | 0.82 | MAPK1 (0.35) | CXCR4MKNK1CYP1A2ALDH1A1MEN1 | |
| SCHEMBL2981463 | 0.81 | JAK2 (0.33) | CYP1A2ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL2972242 | 0.80 | ALDH1A1 (0.33) | CXCR4CYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL2985862 | 0.79 | — | — | |
| SCHEMBL5148401 | 0.78 | USP2 (0.32) | CYP1A2ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL2981319 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-B1 | AMINOPYRIMIDINE COMPOUNDS AS PLK INHIBITORS | AMGEN INC (US) | 2012-11-14 | — | — | EP | claimed |
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |