Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.33 |
| ▸ | USP2 | O75604 | 10/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.33 |
| ▸ | CASP1 | P29466 | 9/20 | 0.33 |
| ▸ | CASP7 | P55210 | 9/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.33 |
| ▸ | MEN1 | O00255 | 7/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.33 |
| ▸ | TSHR | P16473 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | GLA | P06280 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2972242 | 0.87 | ALDH1A1 (0.33) | CXCR4CYP1A2USP2ALDH1A1HSD17B10 | |
| SCHEMBL5147397 | 0.85 | CXCR4 (0.34) | CXCR4MKNK1CYP1A2USP2ALDH1A1 | |
| SCHEMBL2977258 | 0.82 | MEN1 (0.33) | CYP1A2USP2ALDH1A1HSD17B10CASP1 | |
| SCHEMBL5147385 | 0.80 | MAPK1 (0.35) | CXCR4MKNK1CYP1A2USP2ALDH1A1 | |
| SCHEMBL2975981 | 0.79 | ALDH1A1 (0.33) | CYP1A2USP2ALDH1A1HSD17B10CASP1 | |
| SCHEMBL2980191 | 0.77 | JAK2 (0.33) | CYP1A2USP2ALDH1A1HSD17B10CASP1 | |
| SCHEMBL2977483 | 0.76 | MEN1 (0.31) | CYP1A2USP2ALDH1A1HSD17B10CASP1 | |
| SCHEMBL5149162 | 0.75 | PLA2G7 (0.40) | MKNK1CYP1A2USP2ALDH1A1HSD17B10 | |
| SCHEMBL2971994 | 0.74 | MEN1 (0.32) | CYP1A2USP2ALDH1A1HSD17B10CASP1 | |
| SCHEMBL5148401 | 0.73 | USP2 (0.32) | CYP1A2USP2ALDH1A1HSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-B1 | AMINOPYRIMIDINE COMPOUNDS AS PLK INHIBITORS | AMGEN INC (US) | 2012-11-14 | — | — | EP | claimed |