Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.39 |
| ▸ | RAF1 | P04049 | 14/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2972998 | 0.94 | RAF1 (0.41) | BRAFRAF1CLK1CLK2DYRK1A | |
| SCHEMBL2982460 | 0.84 | EIF2AK2 (0.38) | BRAFRAF1CLK1CDK2 | |
| SCHEMBL5147372 | 0.81 | CLK1 (0.41) | BRAFRAF1CLK1CLK2DYRK1A | |
| SCHEMBL2985893 | 0.81 | RAF1 (0.46) | BRAFRAF1CDK2 | |
| SCHEMBL2974386 | 0.77 | ALDH1A1 (0.41) | BRAFRAF1CLK1CCNT1CDK2 | |
| SCHEMBL2986295 | 0.77 | CDK2 (0.35) | BRAFRAF1CLK1CDK2 | |
| SCHEMBL3071448 | 0.77 | CDK2 (0.35) | BRAFRAF1CLK1CDK2 | |
| SCHEMBL5147412 | 0.76 | BRAF (0.36) | BRAFRAF1CLK1CLK2DYRK1A | |
| SCHEMBL5147407 | 0.75 | RAF1 (0.37) | BRAFRAF1CLK1CLK2DYRK1A | |
| SCHEMBL2986787 | 0.75 | CDK2 (0.34) | BRAFRAF1CLK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |