Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.37 |
| ▸ | BRAF | P15056 | 12/20 | 0.37 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147372 | 0.92 | CLK1 (0.41) | RAF1BRAFCLK1CLK2DYRK1A | |
| SCHEMBL2972998 | 0.80 | RAF1 (0.41) | RAF1BRAFCLK1CLK2DYRK1A | |
| SCHEMBL5147410 | 0.76 | ALDH1A1 (0.41) | RAF1BRAFCLK1CDK2ALDH1A1 | |
| SCHEMBL5147404 | 0.75 | BRAF (0.39) | RAF1BRAFCLK1CLK2DYRK1A | |
| SCHEMBL5147395 | 0.75 | CDK2 (0.38) | RAF1BRAFCLK1CDK2ALDH1A1 | |
| SCHEMBL5147412 | 0.75 | BRAF (0.36) | RAF1BRAFCLK1CLK2DYRK1A | |
| SCHEMBL2982460 | 0.70 | EIF2AK2 (0.38) | RAF1BRAFCLK1CDK2 | |
| SCHEMBL5148871 | 0.70 | ALDH1A1 (0.40) | CLK1CDK2ALDH1A1PLA2G7 | |
| SCHEMBL5147359 | 0.69 | ALDH1A1 (0.45) | RAF1BRAFCLK1CLK2DYRK1A | |
| SCHEMBL5146089 | 0.69 | PTGS2 (0.47) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |