Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.50 |
| ▸ | RARG | P13631 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4221224 | 0.81 | RORC (0.36) | RORCPTGER1RARGMAP3K14KDM4E | |
| SCHEMBL3138154 | 0.81 | RORC (0.36) | RORCPTGER1RARGMAP3K14KDM4E | |
| SCHEMBL4227465 | 0.81 | PTGER1 (0.37) | RORCPTGER1RARGGRM2KDM4E | |
| SCHEMBL29496853 | 0.73 | RORC (0.46) | RORCPTGER1GRM2KMT2AKDM4E | |
| SCHEMBL4216581 | 0.72 | SCN4A (0.35) | PTGER1KDM4EALDH1A1POLB | |
| SCHEMBL4221412 | 0.72 | MAPK1 (0.47) | — | |
| SCHEMBL6757088 | 0.71 | PTGER1 (0.57) | RORCPTGER1RARGHSD17B10PPARG | |
| SCHEMBL14863708 | 0.71 | ELANE (0.47) | RORCHSD17B10MAP3K14ELANEKDM4E | |
| SCHEMBL2589646 | 0.71 | ELANE (0.59) | ELANEPOLBSMN1; SMN2 | |
| SCHEMBL5989502 | 0.71 | ELANE (0.73) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684690-A4 | METHODS OF USING AND COMPOSITIONS COMPRISING A JNK INHIBITOR FOR THE TREATMENT AND MANAGEMENT OF ASBESTOS-RELATED DISEASES AND DISORDERS | CELGENE CORP (US) | 2008-10-15 | — | — | EP | disclosed |
| EP-1684690-A2 | METHODS OF USING AND COMPOSITIONS COMPRISING A JNK INHIBITOR FOR THE TREATMENT AND MANAGEMENT OF ASBESTOS-RELATED DISEASES AND DISORDERS | CELGENE CORPORATION (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005046594-A2 | METHODS OF USING AND COMPOSITIONS COMPRISING A JNK INHIBITOR FOR THE TREATMENT AND MANAGEMENT OF ASBESTOS-RELATED DISEASES AND DISORDERS | CELGENE CORPORATION (US) | 2005-05-26 | — | — | WO | disclosed |