Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5145980 | 0.94 | MAPK8 (0.34) | PLA2G7CCNT1CDK9GRM2ALDH1A1 | |
| SCHEMBL2972072 | 0.88 | CA1 (0.34) | CA1CA2CA9DYRK2KCNH2 | |
| SCHEMBL5147508 | 0.87 | PLA2G7 (0.34) | PLA2G7GRM2ALDH1A1 | |
| SCHEMBL5147520 | 0.84 | PLA2G7 (0.35) | PLA2G7GRM2ALDH1A1 | |
| SCHEMBL2981974 | 0.83 | CDK1 (0.31) | — | |
| SCHEMBL2980449 | 0.82 | IKBKB (0.32) | — | |
| SCHEMBL2975963 | 0.82 | MAPK8 (0.34) | — | |
| SCHEMBL5166562 | 0.79 | — | — | |
| SCHEMBL5147316 | 0.79 | PLA2G7 (0.39) | PLA2G7GRM2ALDH1A1 | |
| SCHEMBL5148399 | 0.78 | PLA2G7 (0.39) | PLA2G7GRM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | claimed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | claimed |