Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | BCL2 | P10415 | 2/20 | 0.39 |
| ▸ | RPA1 | P27694 | 2/20 | 0.38 |
| ▸ | MARS1 | P56192 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148769 | 0.88 | MALT1 (0.41) | MALT1CHRNA7PTGS2PTGS1CA1 | |
| SCHEMBL5148795 | 0.88 | MALT1 (0.46) | MALT1CHRNA7PTGS2PTGS1MDM2 | |
| SCHEMBL5148826 | 0.87 | MDM2 (0.43) | MALT1CHRNA7PTGS2PTGS1MDM2 | |
| SCHEMBL5148951 | 0.86 | MALT1 (0.41) | MALT1CHRNA7PTGS2PTGS1MDM2 | |
| SCHEMBL5150854 | 0.86 | MALT1 (0.44) | MALT1CHRNA7PTGS2PTGS1MDM2 | |
| SCHEMBL5148798 | 0.85 | MALT1 (0.44) | MALT1PTGS2PTGS1RPA1CA1 | |
| SCHEMBL5147863 | 0.85 | PTGS2 (0.47) | MALT1CHRNA7PTGS2PTGS1 | |
| SCHEMBL5152420 | 0.85 | PTGS2 (0.42) | MALT1PTGS2PTGS1MDM2MCL1 | |
| SCHEMBL5147787 | 0.85 | PTGS2 (0.41) | MALT1CHRNA7PTGS2PTGS1MDM2 | |
| Hydrochloric Acid SCHEMBL5152030 | 0.83 | MDM2 (0.40) | MALT1CHRNA7PTGS2PTGS1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567503-B1 | PYRAZOLE DERIVATIVES USEFUL AS COX-I INHIBITORS | ASTELLAS PHARMA INC (JP) | 2011-12-21 | — | — | EP | disclosed |
| US-20070112037-A1 | Pyrazole Derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| US-7183306-B2 | Pyrazole derivatives | ASTELLAS PHARMA INC. (JP) | 2007-02-27 | — | — | US | disclosed |
| US-20040116475-A1 | Pyrazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112037-A1 | Pyrazole Derivatives | CYP11B2, CYP11B1, CYP3A43 | MALT1 1227/4885CHRNA7 1626/4885PTGS2 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.