Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | OTC | P00480 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | NPY4R | P50391 | 7/20 | 0.36 |
| ▸ | NPY1R | P25929 | 5/20 | 0.36 |
| ▸ | NPY2R | P49146 | 4/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | RRM1 | P23921 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4273378 | 0.98 | DPP7 (0.40) | DPP7OTCALOX15MEN1CYP1A2 | |
| Arginine SCHEMBL7713117 | 0.96 | DPP7 (0.39) | DPP7OTCALOX15MEN1CYP1A2 | |
| Arginine SCHEMBL21808680 | 0.96 | DPP7 (0.39) | DPP7OTCALOX15MEN1CYP1A2 | |
| Arginine SCHEMBL9238731 | 0.96 | DPP7 (0.39) | DPP7OTCALOX15MEN1CYP1A2 | |
| Arginine SCHEMBL7154973 | 0.96 | DPP7 (0.39) | DPP7OTCALOX15MEN1CYP1A2 | |
| Arginine SCHEMBL6711066 | 0.96 | DPP7 (0.39) | DPP7OTCALOX15MEN1CYP1A2 | |
| Arginine SCHEMBL16194704 | 0.96 | DPP7 (0.39) | DPP7OTCALOX15MEN1CYP1A2 | |
| Arginine SCHEMBL1766115 | 0.96 | DPP7 (0.39) | DPP7OTCALOX15MEN1CYP1A2 | |
| Arginine SCHEMBL3749742 | 0.96 | DPP7 (0.39) | DPP7OTCALOX15MEN1CYP1A2 | |
| Arginine SCHEMBL5653610 | 0.96 | DPP7 (0.39) | DPP7OTCALOX15MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8475773-B2 | Oral hygiene method and formula | MINERAL SCIENCE CO. (US) | 2013-07-02 | — | — | US | claimed |
| US-20120258054-A1 | Oral hygiene method and formula | GILES BRIAN (US) | 2012-10-11 | — | — | US | claimed |
| US-8197797-B2 | Compositions for oral hygiene and method for using same | MINERAL SCIENCE CO. (US) | 2012-06-12 | — | — | US | claimed |
| EP-1755477-A2 | COMPOSITIONS FOR ORAL HYGIENE AND METHOD FOR USING SAME | Cell Ionix , Inc. (US) | 2007-02-28 | — | — | EP | claimed |
| US-20050244344-A1 | Compositions for oral hygiene and method for using same | MINERAL SCIENCE CO. | 2005-11-03 | — | — | US | claimed |
| WO-2005099658-A2 | COMPOSITIONS FOR ORAL HYGIENE AND METHOD FOR USING SAME | CELL IONIX INC. (US) | 2005-10-27 | — | — | WO | claimed |
| US-20150313941-A1 | Composition and methods for amelioration of diseases and related symptoms in domestic animals | MCKINNEY JEFFREY ALAN (US) | 2015-11-05 | — | — | US | disclosed |
| US-20150314005-A1 | Compositions and methods for amelioration of diseases and related symptoms in humans | MCKINNEY JEFFREY ALAN (US) | 2015-11-05 | — | — | US | disclosed |
| US-20140322358-A1 | Compositions and methods for amelioration of chronic renal failure and related symptoms in domestic animals | MCKINNEY JEFFREY ALAN (US) | 2014-10-30 | — | — | US | disclosed |
| WO-2014175929-A2 | COMPOSITIONS AND METHODS FOR AMELIORATION OF CHRONIC RENAL FAILURE AND RELATED SYMPTOMS IN DOMESTIC ANIMALS | MCKINNEY JEFFREY ALAN (US) | 2014-10-30 | — | — | WO | disclosed |