⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564563 | 0.83 | — | — | |
| SCHEMBL187616 | 0.82 | — | — | |
| SCHEMBL28404629 | 0.82 | ALDH1A1 (0.60) | — | |
| SCHEMBL12315103 | 0.82 | ALDH1A1 (0.60) | — | |
| SCHEMBL7870958 | 0.81 | HCAR2 (0.38) | — | |
| SCHEMBL1111518 | 0.80 | — | — | |
| SCHEMBL14504458 | 0.79 | ALDH1A1 (0.50) | — | |
| SCHEMBL2986945 | 0.78 | ALDH1A1 (0.55) | — | |
| SCHEMBL9354654 | 0.78 | — | — | |
| SCHEMBL2984393 | 0.78 | ALDH1A1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2341047-B1 | CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES (JP) | 2014-10-15 | — | — | EP | claimed |
| US-7304079-B2 | Preparing 3-benzothiazolylalkyl-1-indolylacetic acids and esters by cyclizing a 3-(anilinothiocarbonylalkyl)-1-indolylacetic ester with potassium ferricyanide or sodium hydride, optionally deprotecting the acid group; aldose reductase inhibitors for diabetic complications; side effect reduction | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2007-12-04 | — | — | US | claimed |
| US-20070093530-A1 | SUBSTITUTED INDOLEALKANOIC ACIDS | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC | 2007-04-26 | — | — | US | claimed |
| US-7105514-B2 | Substituted indolealkanoic acids | THE INSTITUTE FOR DIBETES DISCOVERY LLC (US) | 2006-09-12 | — | — | US | claimed |
| US-5166212-A | Hypotensive agents, analgesics | CIBA-GEIGY CORPORATION (US) | 1992-11-24 | — | — | US | claimed |
| US-5021430-A | Enkephalinase inhibitors, analgesics, hypotensives | CIBA-GEIGY CORPORATION (US) | 1991-06-04 | — | — | US | claimed |
| US-4939261-A | ANALGESICS, ANTIDEPRESSANTS, HYPOTENSIVE AGENTS, NEUROLEPTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1990-07-03 | — | — | US | claimed |
| US-4914129-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1990-04-03 | — | — | US | claimed |
| US-4889869-A | ANTIALDOSTERONISM AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-12-26 | — | — | US | claimed |
| US-4758584-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | claimed |
| EP-0225292-A2 | Certain N-substituted butyramide derivatives | CIBA-GEIGY AG (CH) | 1987-06-10 | — | — | EP | claimed |
| EP-0188802-A2 | Dibenz (b,e) oxepin derivative and antiallergic agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1986-07-30 | — | — | EP | claimed |
| EP-0185079-A1 | — | CIBA GEIGY AG | 1986-06-25 | — | — | EP | claimed |
| WO-1986000066-A1 | N-SUBSTITUTED BUTYRAMIDE DERIVATIVES | CIBA-GEIGY AG (CH) | 1986-01-03 | — | — | WO | claimed |
| EP-0061765-B1 | BETA-LACTAMS | E.R. SQUIBB & SONS, INC. (US) | 1985-08-28 | — | — | EP | claimed |
| US-4478749-A | AMINO ACID DERTIVATIVES ANTIBIOTICS | E. R. SQUIBB & SONS, INC. (US) | 1984-10-23 | — | — | US | claimed |
| EP-0061765-A1 | Beta-Lactams | E.R. SQUIBB & SONS, INC. (US) | 1982-10-06 | — | — | EP | claimed |
| JP-61152669-A | — | — | None | — | — | JP | disclosed |
| EP-0072013-A1 | Pyrrole compounds as anti-inflammatory and analgesic agents | MERCK & CO. INC. (US) | 1983-02-16 | — | — | EP | disclosed |
| EP-0061765-A1 | Beta-Lactams | E.R. SQUIBB & SONS, INC. (US) | 1982-10-06 | — | — | EP | disclosed |