Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2471847 | 0.83 | KDM4E (0.41) | GRM2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL19272942 | 0.77 | PSMB5 (0.41) | GRM2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL3207562 | 0.75 | ALDH1A1 (0.46) | GRM2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL24188646 | 0.72 | PSMB5 (0.45) | GRM2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL31186680 | 0.71 | POLB (0.55) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL1562526 | 0.71 | POLB (0.55) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL28280669 | 0.69 | KDM4E (0.51) | GRM2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL30502987 | 0.68 | POLB (0.52) | GRM2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL4101758 | 0.68 | POLB (0.52) | GRM2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL15448472 | 0.68 | NQO2 (0.42) | GRM2ALDH1A1MAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070200096-A1 | Doped lithium quinolate | OLED-T LIMITED (GB) | 2007-08-30 | — | — | US | claimed |