Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Vitamin K3H2. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vitamin K3H2 SCHEMBL27560223 | 0.98 | HTT (0.78) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL987810 | 0.96 | HTT (0.75) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL297164 | 0.90 | HTT (1.00) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL29525544 | 0.90 | HTT (1.00) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL9223417 | 0.90 | HTT (0.70) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL2887680 | 0.88 | HTT (0.95) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL28664356 | 0.85 | HTT (0.81) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL515420 | 0.85 | HTT (0.81) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL516200 | 0.85 | HTT (0.81) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL5075246 | 0.85 | HTT (0.81) | HTTLMNAPKMMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 393 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212214-B2 | Methods of increasing the expression yield of vitamin K-dependent proteins | CSL LIMITED (AU) | 2015-12-15 | — | — | US | claimed |
| US-20130261603-A1 | TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANTI-PROLIFERATE AND ANTI-INFLAMMATORY DRUGS | LUTONIX, INC. (US) | 2013-10-03 | — | — | US | claimed |
| US-20130253475-A1 | TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANTI-PROLIFERATE AND ANTI-INFLAMMATORY DRUGS | LUTONIX, INC. (US) | 2013-09-26 | — | — | US | claimed |
| US-20130197431-A1 | DRUG RELEASING COATINGS FOR MEDICAL DEVICES | LUTONIX, INC. (US) | 2013-08-01 | — | — | US | claimed |
| US-20130197435-A1 | MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING OILS, FATTY ACIDS, AND/OR LIPIDS | LUTONIX, INC. (US) | 2013-08-01 | — | — | US | claimed |
| US-20130189190-A1 | MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING A THERAPEUTIC AGENT AND A CONTRAST AGENT | LUTONIX, INC. (US) | 2013-07-25 | — | — | US | claimed |
| US-20130189329-A1 | DRUG RELEASING COATINGS FOR MEDICAL DEVICES | LUTONIX, INC. (US) | 2013-07-25 | — | — | US | claimed |
| US-8414526-B2 | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids | LUTONIX, INC. (US) | 2013-04-09 | — | — | US | claimed |
| US-8414525-B2 | Drug releasing coatings for medical devices | LUTONIX, INC. (US) | 2013-04-09 | — | — | US | claimed |
| EP-2550030-A1 | DRUG RELEASING COATINGS FOR MEDICAL DEVICES | Lutonix, Inc. (US) | 2013-01-30 | — | — | EP | claimed |
| US-20080276935-A1 | TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANTI-PROLIFERATE AND ANTI-INFLAMMATORY DRUGS | LUTONIX, INC. | 2008-11-13 | — | — | US | claimed |
| US-20080255509-A1 | MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING OILS, FATTY ACIDS, AND/OR LIPIDS | LUTONIX, INC. | 2008-10-16 | — | — | US | claimed |
| US-20080255508-A1 | Such as balloon and stents; medical device with overcoating of drug with additive; bioavailability | LUTONIX, INC. | 2008-10-16 | — | — | US | claimed |
| US-20080255510-A1 | Layer containing therapeutic agent, adjuvant and contrast agent ; high speed supplying agent to tissue; adjuvant contains hyfrophilic part and drug affinity part; overcoating exterior surface of medical device | LUTONIX, INC. | 2008-10-16 | — | — | US | claimed |
| US-20080175887-A1 | drug delivering by oral, nasal or pulmonary administration, of rapamycin or paclitaxel drug; additive enhances absorption of drug into body tissue; PEG-fatty acids esters, PEG-fatty alcohol ethers, polyethylene glycol sorbitan fatty acid esters, polyoxyethylene-polyoxypropylene block copolymers | LUTONIX, INC. | 2008-07-24 | — | — | US | claimed |
| WO-2008063581-A2 | TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANTI-PROLIFERATE AND ANTI-INFLAMMATORY DRUGS | LUTONIX, INC. (US) | 2008-05-29 | — | — | WO | claimed |
| WO-2008063576-A2 | DRUG RELEASING COATINGS FOR MEDICAL DEVICES | LUTONIX, INC. (US) | 2008-05-29 | — | — | WO | claimed |
| US-20080118544-A1 | Such as a balloon catheter or a stent; a drug not enclosed in micelles or encapsulated in particles or controlled release carriers and an additive having hydrophobic and hydrophilic portions; improved pharmacokinetics and bioavailability | LUTONIX, INC. | 2008-05-22 | — | — | US | claimed |
| EP-0998925-A1 | MEDICINAL COMPOSITIONS FOR TOPICAL ADMINISTRATION CONTAINING VITAMIN D AND VITAMIN K | New Vision Co., Ltd. (JP) | 2000-05-10 | — | — | EP | claimed |
| US-5876709-A | Ophthalmic composition containing active Vitamin D | NEW VISION CO., LTD. (JP) | 1999-03-02 | — | — | US | claimed |