Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Vitamin K3H2. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vitamin K3H2 SCHEMBL27560223 | 0.98 | HTT (0.78) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL515182 | 0.96 | HTT (0.81) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL2887680 | 0.89 | HTT (0.95) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL297164 | 0.87 | HTT (1.00) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL29525544 | 0.87 | HTT (1.00) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL9223417 | 0.86 | HTT (0.70) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL5075246 | 0.81 | HTT (0.81) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL515420 | 0.81 | HTT (0.81) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL28664356 | 0.81 | HTT (0.81) | HTTLMNAPKMMAPTMEN1 | |
| Vitamin K3H2 SCHEMBL516200 | 0.81 | HTT (0.81) | HTTLMNAPKMMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451963-A1 | METHOD OF INCREASING THE EXPRESSION YIELD OF VITAMIN K-DEPENDENT PROTEINS | CSL Limited (AU) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011003153-A1 | METHOD OF INCREASING THE EXPRESSION YIELD OF VITAMIN K-DEPENDENT PROTEINS | CSL LIMITED (AU) | 2011-01-13 | — | — | WO | disclosed |