Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.43 |
| ▸ | BCL2 | P10415 | 3/20 | 0.43 |
| ▸ | RPA1 | P27694 | 6/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 4/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148755 | 0.93 | MDM2 (0.40) | MDM2MCL1BCL2RPA1MALT1 | |
| SCHEMBL14504646 | 0.90 | MDM2 (0.45) | MDM2MCL1BCL2RPA1MALT1 | |
| SCHEMBL5150854 | 0.89 | MALT1 (0.44) | MDM2MCL1BCL2RPA1MALT1 | |
| Hydrochloric Acid SCHEMBL5148947 | 0.87 | MDM2 (0.43) | MDM2MCL1BCL2RPA1MALT1 | |
| SCHEMBL5148813 | 0.87 | RPA1 (0.47) | MDM2MCL1BCL2RPA1MALT1 | |
| SCHEMBL5148826 | 0.86 | MDM2 (0.43) | MDM2MCL1BCL2RPA1MALT1 | |
| SCHEMBL5148944 | 0.86 | FABP4 (0.43) | MDM2MCL1BCL2RPA1MALT1 | |
| SCHEMBL6208574 | 0.86 | MDM2 (0.41) | MDM2MCL1BCL2RPA1MALT1 | |
| SCHEMBL5148724 | 0.84 | BCL2 (0.45) | MDM2MCL1BCL2RPA1OXTR | |
| SCHEMBL5171475 | 0.83 | RPA1 (0.42) | MDM2MCL1BCL2RPA1MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567503-B1 | PYRAZOLE DERIVATIVES USEFUL AS COX-I INHIBITORS | ASTELLAS PHARMA INC (JP) | 2011-12-21 | — | — | EP | disclosed |
| US-20070112037-A1 | Pyrazole Derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| US-7183306-B2 | Pyrazole derivatives | ASTELLAS PHARMA INC. (JP) | 2007-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112037-A1 | Pyrazole Derivatives | CYP11B2, CYP11B1, CYP3A43 | MDM2 1492/4885MCL1 1748/4885BCL2 2334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.