Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.40 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | EPM2A | O95278 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655103 | 0.82 | PFKFB3 (0.41) | PFKFB3PFKFB4EPM2APTPN2PTPN1 | |
| SCHEMBL4655102 | 0.82 | PFKFB3 (0.41) | PFKFB3PFKFB4EPM2APTPN2PTPN1 | |
| SCHEMBL14449260 | 0.74 | TTR (0.42) | ESR1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4655134 | 0.72 | CYP2A6 (0.47) | PFKFB3PFKFB4EPM2APTPN2PTPN1 | |
| SCHEMBL4655145 | 0.71 | ESR1 (0.37) | ESR1PPARANPC1MEN1KMT2A | |
| SCHEMBL4655146 | 0.71 | ESR1 (0.37) | ESR1PPARANPC1MEN1KMT2A | |
| SCHEMBL4654028 | 0.71 | PFKFB3 (0.38) | PFKFB3PFKFB4EPM2APTPN2PTPN1 | |
| SCHEMBL22310361 | 0.70 | ALDH1A1 (0.39) | AAK1NPC1RECQLRAB9ASMN1; SMN2 | |
| SCHEMBL454010 | 0.70 | SMN1; SMN2 (0.51) | ESR1NPC1RECQLRAB9ASMN1; SMN2 | |
| SCHEMBL454011 | 0.70 | SMN1; SMN2 (0.51) | ESR1NPC1RECQLRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740568-A2 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF CARDIOVASCULAR DISEASE. | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005077926-A2 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF CARDIOVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |