Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655146 | 1.00 | ESR1 (0.37) | ESR1KMT2AMEN1NPC1RXFP1 | |
| SCHEMBL4655102 | 0.89 | PFKFB3 (0.41) | KMT2AMEN1NPC1RXFP1AKR1C3 | |
| SCHEMBL4655103 | 0.89 | PFKFB3 (0.41) | KMT2AMEN1NPC1RXFP1AKR1C3 | |
| SCHEMBL14449260 | 0.83 | TTR (0.42) | ESR1NPC1 | |
| SCHEMBL19178907 | 0.79 | TUBB4A (0.48) | KMT2AMEN1NPC1RXFP1MAPK1 | |
| SCHEMBL4655105 | 0.79 | CYP2A6 (0.40) | KMT2AMEN1NPC1RXFP1ESR2 | |
| SCHEMBL2895958 | 0.74 | GPR35 (0.58) | KMT2AMEN1NPC1RXFP1 | |
| SCHEMBL4654250 | 0.71 | ESR1 (0.42) | ESR1KMT2AMEN1PPARA | |
| SCHEMBL4654254 | 0.71 | ESR1 (0.42) | ESR1KMT2AMEN1PPARA | |
| SCHEMBL5154338 | 0.71 | PFKFB3 (0.40) | ESR1KMT2AMEN1NPC1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740568-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF CARDIOVASCULAR DISEASE. | SMITHKLINE BEECHAM CORP (US) | 2008-11-26 | — | — | EP | disclosed |
| US-20070155805-A1 | Benzofuran and bezothiophene derivatives useful for the treatment of cardiovascular disease | SMITHKLINE BEECHAM CORPORATION | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155805-A1 | Benzofuran and bezothiophene derivatives useful for the treatment of cardiovascular disease | ABAT, BPTF, TNNT2 | ESR1 2254/4885KMT2A 1404/4885MEN1 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.