SCHEMBL5154532

SCHEMBL5154532

COC(C)(C)O[C@@H](CO)c1cccc(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.48
CYP2B6 P20813 1/20 0.38
SLC6A4 P31645 6/20 0.36
SLC6A2 P23975 6/20 0.36
SLC6A3 Q01959 2/20 0.36
ACP3 P15309 1/20 0.36
CHRNA1 P02708 1/20 0.35
CHRNG P07510 1/20 0.35
ITGA5 P08648 1/20 0.35
CHRNB1 P11230 1/20 0.35
CHRNB2 P17787 1/20 0.35
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
CYP2C19 P33261 1/20 0.35
HRH1 P35367 1/20 0.35
CHRNA7 P36544 1/20 0.35
OPRK1 P41145 1/20 0.35
CHRNA4 P43681 1/20 0.35
CHRND Q07001 1/20 0.35
KCNH2 Q12809 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5154543 1.00 AOC3 (0.48) AOC3CYP2B6SLC6A4SLC6A2SLC6A3
SCHEMBL5159911 0.83 AOC3 (0.41) AOC3SLC6A4SLC6A2SMN1; SMN2MEN1
SCHEMBL5159898 0.83 AOC3 (0.41) AOC3SLC6A4SLC6A2SMN1; SMN2MEN1
SCHEMBL17724418 0.82 GSR (0.45) SLC6A4SLC6A2SLC6A3CYP2C19BLM
SCHEMBL24615882 0.80 AOC3 (0.64) AOC3SLC6A4SLC6A2SLC6A3ACP3
SCHEMBL9063602 0.78 AOC3 (0.43) AOC3CYP2B6SLC6A4SLC6A2ACP3
SCHEMBL3681293 0.74 ADRB2 (0.42) AOC3IDO1ALDH1A1BLMMEN1
SCHEMBL3681295 0.74 ADRB2 (0.42) AOC3IDO1ALDH1A1BLMMEN1
SCHEMBL28076433 0.71 MAPT (0.46) AOC3CYP2B6SLC6A4SLC6A2SLC6A3
SCHEMBL18022513 0.70 AOC3 (0.44) AOC3CYP2B6SLC6A4SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1236714-B1 ACETALSULFONATE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING STYRENE OXIDE DERIVATIVE MITSUBISHI RAYON CO (JP) 2007-01-17 EP disclosed
US-6642395-B1 Esterifying mandelic acid derivative; protecting hydroxyl group and reducing ester; sulfonating and epoxidizing MITSUBISHI RAYON CO., LTD. (JP) 2003-11-04 US disclosed
EP-1236714-A1 ACETALSULFONATE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING STYRENE OXIDE DERIVATIVE Mitsubishi Rayon Co., Ltd. (JP) 2002-09-04 EP disclosed