Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003007 | 0.88 | AOC3 (0.43) | AOC3SLC6A4IDO1SLC6A2DHFR | |
| SCHEMBL7151078 | 0.87 | AOC3 (0.46) | AOC3SLC6A4IDO1DHFRTDO2 | |
| SCHEMBL7392343 | 0.87 | AOC3 (0.46) | AOC3SLC6A4IDO1DHFRTDO2 | |
| SCHEMBL6439346 | 0.84 | CA2 (0.35) | — | |
| SCHEMBL6439350 | 0.84 | CA2 (0.35) | — | |
| SCHEMBL15229070 | 0.83 | SLC6A2 (0.38) | SLC6A4SLC6A2 | |
| SCHEMBL14984000 | 0.83 | GSR (0.44) | AOC3SLC6A4SLC6A2 | |
| SCHEMBL1739510 | 0.83 | GSR (0.44) | AOC3SLC6A4SLC6A2 | |
| SCHEMBL8405099 | 0.83 | GSR (0.44) | AOC3SLC6A4SLC6A2 | |
| SCHEMBL23192881 | 0.80 | DHFR (0.44) | AOC3ACP3SLC6A4SLC6A2DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2820009-A1 | SERINE/THREONINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2015-01-07 | — | — | EP | disclosed |
| WO-2013130976-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2013-09-06 | — | — | WO | disclosed |
| US-5491134-A | TREATING DIABETES, OBESITY, ACHALASIA, GASTORINTESTINAL DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-02-13 | — | — | US | disclosed |
| US-5321036-A | Treatment of diabetes, obesity and gastrointestinal disorders | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-14 | — | — | US | disclosed |