Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.56 |
| ▸ | F10 | P00742 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | NOS3 | P29474 | 2/20 | 0.47 |
| ▸ | NOS1 | P29475 | 2/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4253161 | 1.00 | LOXL2 (0.56) | LOXL2F10RAB9AGAAKDM1A | |
| SCHEMBL4253164 | 1.00 | LOXL2 (0.56) | LOXL2F10RAB9AGAAKDM1A | |
| Hydrochloric Acid SCHEMBL6743119 | 0.98 | LOXL2 (0.54) | LOXL2F10RAB9AGAAKDM1A | |
| Hydrochloric Acid SCHEMBL18300738 | 0.98 | LOXL2 (0.54) | LOXL2F10RAB9AGAAKDM1A | |
| Hydrochloric Acid SCHEMBL6743124 | 0.98 | LOXL2 (0.54) | LOXL2F10RAB9AGAAKDM1A | |
| Hydrochloric Acid SCHEMBL18300737 | 0.98 | LOXL2 (0.54) | LOXL2F10RAB9AGAAKDM1A | |
| SCHEMBL6651592 | 0.83 | TAAR1 (0.50) | LOXL2RAB9AGAAKDM1ANOS3 | |
| SCHEMBL21215222 | 0.83 | KDM1A (0.60) | RAB9AGAAKDM1ANPC1LMNA | |
| SCHEMBL320861 | 0.82 | PRSS1 (0.56) | RAB9AGAAKDM1ANOS3NOS1 | |
| SCHEMBL320862 | 0.82 | PRSS1 (0.56) | RAB9AGAAKDM1ANOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019150219-A2 | NOVEL OXADIAZOLES | PI INDUSTRIES LTD. (IN) | 2019-08-08 | — | — | WO | disclosed |
| EP-3466961-A1 | PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF | Li, Min (US) | 2019-04-10 | — | — | EP | disclosed |
| US-10144746-B2 | Bridged bicyclic kallikrein inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2018-12-04 | — | — | US | disclosed |
| US-20180194780-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2018-07-12 | — | — | US | disclosed |
| US-9815853-B2 | Bridged bicyclic kallikrein inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-9815853-B2 | Bridged bicyclic kallikrein inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| WO-2016201052-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2016-12-15 | — | — | WO | disclosed |
| WO-2016201052-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2016-12-15 | — | — | WO | disclosed |
| US-20160362427-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2016-12-15 | — | — | US | disclosed |
| US-20160362427-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2016-12-15 | — | — | US | disclosed |
| US-9266828-B2 | Inhibitors of Furin and other pro-protein convertases | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-02-23 | — | — | US | disclosed |
| US-9266828-B2 | Inhibitors of Furin and other pro-protein convertases | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-02-23 | — | — | US | disclosed |
| US-20150073054-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2015-03-12 | — | — | US | disclosed |
| US-20150073054-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2015-03-12 | — | — | US | disclosed |
| US-20150051138-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-02-19 | — | — | US | disclosed |
| US-20150051138-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-02-19 | — | — | US | disclosed |
| WO-2013138666-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-09-19 | — | — | WO | disclosed |
| WO-2013138665-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-09-19 | — | — | WO | disclosed |
| EP-1215213-B1 | Bicyclic amino-pyrazone derivatives, their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2007-01-17 | — | — | EP | disclosed |
| EP-1215213-A2 | Bicyclic amino-pyrazone derivatives, their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10144746-B2 | Bridged bicyclic kallikrein inhibitors | KLKB1, KLK1, KLK2 | LOXL2 1090/4885F10 544/4885RAB9A 2869/4885 |
| US-20160362427-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | KLKB1, KLK1, KLK2 | LOXL2 1090/4885F10 544/4885RAB9A 2869/4885 |
| US-20180194780-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | KLKB1, KLK1, KLK2 | LOXL2 1090/4885F10 544/4885RAB9A 2869/4885 |
| US-20150051138-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | FURIN, PREP, PCSK6 | LOXL2 2034/4885F10 445/4885RAB9A 517/4885 |
| US-20150073054-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | FURIN, PREP, PCSK6 | LOXL2 2034/4885F10 445/4885RAB9A 517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.