Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511453 | 0.86 | CA2 (0.45) | LMNASLC6A3PDPK1SMN1; SMN2CYP2D6 | |
| SCHEMBL12854153 | 0.77 | CYP2C19 (0.41) | SLC6A3SMN1; SMN2CYP2D6CYP2C19PKM | |
| SCHEMBL88641 | 0.75 | CA2 (0.64) | LMNAKMT2ASMN1; SMN2FAAHPRSS1 | |
| SCHEMBL378027 | 0.74 | PDPK1 (0.50) | SLC6A3PDPK1SMN1; SMN2PLA2G4AKDM4E | |
| SCHEMBL28332352 | 0.73 | CA2 (0.61) | LMNAKMT2ASMN1; SMN2FAAHPRSS1 | |
| Hydrochloric Acid SCHEMBL11574583 | 0.73 | CA2 (0.61) | LMNAKMT2ASMN1; SMN2FAAHPRSS1 | |
| SCHEMBL7617248 | 0.73 | PDPK1 (0.48) | SLC6A3PDPK1SMN1; SMN2PLA2G4AKDM4E | |
| SCHEMBL6657646 | 0.73 | PDPK1 (0.48) | LMNASLC6A3PDPK1SMN1; SMN2PLA2G4A | |
| Hydrochloric Acid SCHEMBL3930720 | 0.73 | PDPK1 (0.48) | SLC6A3PDPK1SMN1; SMN2PLA2G4AKDM4E | |
| SCHEMBL8558270 | 0.72 | PDPK1 (0.41) | LMNAKMT2APDPK1SMN1; SMN2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866277-A2 | SULFONYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | CELERA GENOMICS (US) | 2007-12-19 | — | — | EP | claimed |
| WO-2006102535-A2 | SULFONYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | CELERA GENOMICS (US) | 2006-09-28 | — | — | WO | claimed |