Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140031 | 0.91 | ALDH1A1 (0.51) | ALDH1A1KDM4ERXFP1FKBP1APOLB | |
| SCHEMBL3105671 | 0.90 | ALDH1A1 (0.60) | ALDH1A1KDM4ERXFP1FKBP1APOLB | |
| SCHEMBL12509430 | 0.82 | FKBP1A (0.64) | ALDH1A1KDM4ERXFP1FKBP1APOLB | |
| SCHEMBL3088888 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4ERXFP1FKBP1APOLB | |
| SCHEMBL3094736 | 0.77 | ALDH1A1 (0.60) | ALDH1A1POLBMAPTMMP2MMP9 | |
| SCHEMBL31086922 | 0.76 | ALDH1A1 (0.72) | ALDH1A1POLBKMT2ATSHRHTT | |
| SCHEMBL3097288 | 0.75 | HCRTR1 (0.63) | ALDH1A1MAPTMMP2MMP9TSHR | |
| SCHEMBL28926528 | 0.75 | ALDH1A1 (0.61) | ALDH1A1KMT2AMMP2MMP9TSHR | |
| SCHEMBL28926525 | 0.75 | ALDH1A1 (0.61) | ALDH1A1KMT2AMMP2MMP9TSHR | |
| SCHEMBL20271477 | 0.75 | BRD4 (0.71) | ALDH1A1KDM4EMAPTKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912634-A2 | PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Healthcare, LLC (US) | 2008-04-23 | — | — | EP | claimed |
| WO-2007016538-A2 | PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2007-02-08 | — | — | WO | claimed |