Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139444 | 0.90 | CYP11B1 (0.46) | KDM4EKMT2ACA2CYP11B1CYP11B2 | |
| SCHEMBL5109650 | 0.89 | MAPK1 (0.48) | KDM4EKMT2ACYP11B1CYP11B2CYP17A1 | |
| SCHEMBL5103940 | 0.89 | CYP17A1 (0.48) | KDM4EKMT2ACA2CYP11B1CYP11B2 | |
| SCHEMBL5100706 | 0.89 | CYP11B1 (0.43) | KDM4EKMT2ACYP11B1CYP11B2CYP17A1 | |
| SCHEMBL5096786 | 0.84 | COMT (0.58) | KDM4EKMT2ACYP11B1CYP11B2CYP17A1 | |
| SCHEMBL5111022 | 0.81 | FGFR1 (0.49) | KDM4EKMT2ACYP11B1CYP11B2CYP17A1 | |
| SCHEMBL5110846 | 0.80 | TACR3 (0.43) | CYP11B1CYP11B2CYP17A1PDE4APDE4B | |
| SCHEMBL5096839 | 0.80 | HTR2A (0.39) | KDM4EKMT2ACYP11B1CYP11B2CYP17A1 | |
| SCHEMBL5104043 | 0.80 | GSK3A (0.46) | KDM4EKMT2ACYP17A1ALDH1A1GAA | |
| SCHEMBL14311768 | 0.79 | CYP11B1 (0.57) | KDM4ECYP11B1CYP11B2TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008004100-A2 | THERAPEUTIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |