Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5156205 | 0.89 | KDM4E (0.49) | CYP11B1CYP11B2CYP17A1KMT2AMEN1 | |
| SCHEMBL5139444 | 0.86 | CYP11B1 (0.46) | CYP11B1CYP11B2CYP17A1KMT2AMEN1 | |
| SCHEMBL5109650 | 0.85 | MAPK1 (0.48) | CYP11B1CYP11B2CYP17A1KMT2AMEN1 | |
| SCHEMBL5153636 | 0.84 | LMNA (0.48) | CYP11B1CYP11B2KMT2AMEN1COMT | |
| SCHEMBL5103940 | 0.83 | CYP17A1 (0.48) | CYP11B1CYP11B2CYP17A1KMT2ACOMT | |
| SCHEMBL5096786 | 0.81 | COMT (0.58) | CYP11B1CYP11B2CYP17A1KMT2AMEN1 | |
| SCHEMBL5111022 | 0.78 | FGFR1 (0.49) | CYP11B1CYP11B2CYP17A1KMT2AMEN1 | |
| SCHEMBL5110846 | 0.77 | TACR3 (0.43) | CYP11B1CYP11B2CYP17A1RAB9AMAPT | |
| SCHEMBL5104043 | 0.77 | GSK3A (0.46) | CYP17A1KMT2AMEN1RAB9AMAPT | |
| SCHEMBL14311768 | 0.76 | CYP11B1 (0.57) | CYP11B1CYP11B2RAB9AMAPTCOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008004100-A2 | THERAPEUTIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |