Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | COMT | P21964 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5096786 | 0.89 | COMT (0.58) | CYP11B1CYP11B2GSK3AGSK3BDYRK1A | |
| SCHEMBL5150253 | 0.82 | LTA4H (0.47) | CYP11B1CYP11B2GSK3AGSK3BCOMT | |
| SCHEMBL5156205 | 0.81 | KDM4E (0.49) | CYP11B1CYP11B2COMTMAPTRAB9A | |
| SCHEMBL5104043 | 0.79 | GSK3A (0.46) | GSK3AGSK3BDYRK1ACOMTMAPT | |
| SCHEMBL5139444 | 0.79 | CYP11B1 (0.46) | CYP11B1CYP11B2GSK3AGSK3BDYRK1A | |
| SCHEMBL5110822 | 0.79 | GSK3A (0.46) | CYP11B1CYP11B2GSK3AGSK3BDYRK1A | |
| SCHEMBL5100672 | 0.78 | ALPL (0.49) | CYP11B1CYP11B2GSK3AGSK3BDYRK1A | |
| SCHEMBL14311768 | 0.78 | CYP11B1 (0.57) | CYP11B1CYP11B2COMTMAPTNPC1 | |
| SCHEMBL5103933 | 0.78 | CYP11B1 (0.47) | CYP11B1CYP11B2COMTRAB9AROCK1 | |
| SCHEMBL5109650 | 0.78 | MAPK1 (0.48) | CYP11B1CYP11B2COMTMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008004100-A2 | THERAPEUTIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |