Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 9/20 | 0.61 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5156363 | 1.00 | TBXAS1 (0.61) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9732341 | 0.85 | TBXAS1 (0.68) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9732343 | 0.85 | TBXAS1 (0.68) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL8528974 | 0.81 | TBXAS1 (0.46) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL30479399 | 0.78 | TBXAS1 (0.53) | TBXAS1 | |
| SCHEMBL10444608 | 0.77 | TBXAS1 (0.91) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5354522 | 0.76 | TBXAS1 (1.00) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5354515 | 0.76 | TBXAS1 (1.00) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL10618801 | 0.75 | TBXAS1 (0.48) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL10618822 | 0.75 | TBXAS1 (0.48) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242068-A4 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | NITROMED INC (US) | 2007-04-25 | — | — | EP | claimed |
| EP-1242068-A1 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | Nitromed, Inc. (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001032167-A1 | ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION | NITROMED, INC. (US) | 2001-05-10 | — | — | WO | claimed |