Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLA1 | P09884 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15757238 | 0.77 | OPRK1 (0.56) | CYP2D6CYP2C19MAPTSMN1; SMN2POLB | |
| SCHEMBL3198284 | 0.77 | PDGFRB (0.44) | CYP2D6CYP2C19KMT2APOLA1OPRK1 | |
| SCHEMBL3198280 | 0.77 | PDGFRB (0.44) | CYP2D6CYP2C19KMT2APOLA1OPRK1 | |
| SCHEMBL17315333 | 0.76 | KMT2A (0.47) | CYP2D6CYP2C19KMT2APOLA1OPRK1 | |
| SCHEMBL9873035 | 0.76 | CYP2D6 (0.52) | CYP2D6CYP2C19MAPTSMN1; SMN2POLB | |
| SCHEMBL9470712 | 0.75 | CYP2D6 (0.48) | CYP2D6CYP2C19MAPTSMN1; SMN2POLB | |
| SCHEMBL13153722 | 0.75 | NUDT1 (0.59) | CYP2D6CYP2C19MAPTSMN1; SMN2POLB | |
| SCHEMBL1316806 | 0.75 | NUDT1 (0.64) | CYP2D6CYP2C19KMT2APOLA1OPRK1 | |
| SCHEMBL17315347 | 0.74 | NUDT1 (0.72) | CYP2D6HRH4NUDT1HSP90AA1HSP90AB1 | |
| SCHEMBL9872475 | 0.74 | CYP2D6 (0.47) | CYP2D6CYP2C19MAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| US-20070185075-A1 | Pyrimidine derivatives | PFIZER LIMITED | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185075-A1 | Pyrimidine derivatives | TYMS, DPYD, TYMP | CYP2D6 179/4885CYP2C19 177/4885MAPT 3183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.