Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507281 | 1.00 | HSD11B1 (0.46) | HSD11B1CYP2C9EPHX2EPHX1CNR2 | |
| SCHEMBL6506890 | 0.84 | EPHX1 (0.55) | EPHX2EPHX1CNR2KDM4EPKM | |
| SCHEMBL5157056 | 0.83 | HSD11B1 (0.53) | HSD11B1EPHX2CNR2HSD17B10L3MBTL1 | |
| SCHEMBL6503057 | 0.81 | HSD11B1 (0.52) | HSD11B1CYP2C9EPHX2EPHX1NR1H2 | |
| SCHEMBL6502476 | 0.81 | HSD11B1 (0.57) | HSD11B1EPHX2EPHX1CNR2HSD17B10 | |
| SCHEMBL6504279 | 0.78 | HSD11B1 (0.51) | HSD11B1EPHX2EPHX1CNR2HSD17B10 | |
| SCHEMBL6504975 | 0.78 | CYP1A2 (0.51) | HSD11B1CYP2C9EPHX2EPHX1HSD17B10 | |
| SCHEMBL5157466 | 0.73 | HSD11B1 (0.58) | HSD11B1CYP2C9EPHX2EPHX1HSD17B10 | |
| SCHEMBL6507024 | 0.73 | HSD11B1 (0.44) | HSD11B1EPHX2HSD17B10L3MBTL1 | |
| SCHEMBL5158011 | 0.71 | HSD11B1 (0.51) | HSD11B1EPHX2HSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |