Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159434 | 0.86 | MAPT (0.58) | LMNAGLANPSR1CYP1A2CYP2C9 | |
| SCHEMBL5159821 | 0.86 | MAOB (0.58) | LMNAGLANPSR1ALDH1A1KDM4E | |
| SCHEMBL5159432 | 0.86 | MAOB (0.49) | LMNAGLANPSR1MCL1ALDH1A1 | |
| SCHEMBL5685559 | 0.85 | GLA (0.51) | LMNAGLANPSR1MCL1ALDH1A1 | |
| SCHEMBL5157804 | 0.82 | LMNA (0.48) | LMNAGLANPSR1ALDH1A1KDM4E | |
| SCHEMBL5157453 | 0.82 | KDM4E (0.53) | LMNAGLANPSR1ALDH1A1KDM4E | |
| SCHEMBL10962452 | 0.81 | GLA (0.81) | LMNAGLANPSR1MCL1ALDH1A1 | |
| SCHEMBL10962466 | 0.81 | GLA (0.81) | LMNAGLANPSR1MCL1ALDH1A1 | |
| SCHEMBL10962462 | 0.81 | GLA (0.81) | LMNAGLANPSR1MCL1ALDH1A1 | |
| SCHEMBL5688492 | 0.81 | MAOB (0.59) | LMNAGLANPSR1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-21 | — | — | US | claimed |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2004-04-15 | — | — | US | claimed |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2003-06-12 | — | — | US | claimed |
| EP-1752446-A2 | Compounds for modulating cell proliferation | HSC Research and Development Limited Partnership (CA) | 2007-02-14 | — | — | EP | disclosed |
| EP-1272457-B9 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-12-20 | — | — | EP | disclosed |
| US-20060241084-A1 | Inhibition of vascular endothelial growth factor | THE HOSPITAL FOR SICK CHILDREN (CA) | 2006-10-26 | — | — | US | disclosed |
| EP-1272457-B1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-08-23 | — | — | EP | disclosed |
| US-7012095-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2006-03-14 | — | — | US | disclosed |
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-21 | — | — | US | disclosed |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2004-04-15 | — | — | US | disclosed |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2003-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241084-A1 | Inhibition of vascular endothelial growth factor | VEGFA, FLT4, FLT1 | LMNA 4824/4885GLA 724/4885NPSR1 1189/4885 |
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, CCNI | LMNA 1972/4885GLA 3471/4885NPSR1 3729/4885 |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, CCNI | LMNA 1972/4885GLA 3471/4885NPSR1 3729/4885 |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, MCL1 | LMNA 2144/4885GLA 3382/4885NPSR1 3669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.