Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157965 | 0.86 | HSD11B1 (0.61) | HSD11B1HSD17B10L3MBTL1NPC1EPHX1 | |
| SCHEMBL6503057 | 0.84 | HSD11B1 (0.52) | HSD11B1HSD17B10L3MBTL1EPHX1EPHX2 | |
| SCHEMBL5160276 | 0.80 | HSD11B1 (0.62) | HSD11B1HSD17B10L3MBTL1NPC1EPHX1 | |
| SCHEMBL6504698 | 0.80 | HSD11B1 (0.62) | HSD11B1HSD17B10L3MBTL1NPC1EPHX1 | |
| SCHEMBL6502476 | 0.78 | HSD11B1 (0.57) | HSD11B1HSD17B10L3MBTL1NPC1EPHX1 | |
| SCHEMBL5177177 | 0.77 | HSD11B1 (0.56) | HSD11B1HSD17B10L3MBTL1NPC1EPHX1 | |
| SCHEMBL6510781 | 0.75 | HSD11B1 (0.56) | HSD11B1HSD17B10L3MBTL1NPC1EPHX1 | |
| SCHEMBL6503059 | 0.73 | HSD11B1 (0.47) | HSD11B1HSD17B10L3MBTL1NPC1EPHX1 | |
| SCHEMBL5312558 | 0.72 | HSD11B1 (0.65) | HSD11B1HSD17B10L3MBTL1NPC1EPHX1 | |
| SCHEMBL6510795 | 0.72 | HSD11B1 (0.53) | HSD11B1HSD17B10L3MBTL1NPC1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |